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【正文】 ues and ans of the immune system Primary lymphoid ans the bone marrow the thymus gland Secondary lymphoid ans the spleen lymph nodes Mucosalassociated lymphoid tissue Functions of lymphoid ans 1. the place in which proliferation of HSC take place 2. the place in which development and maturation of B cells occur 3. The lymphoid progenitor cells are transported by circulating blood to the thymus and differentiate into fuctional T lymphocytes Bone marrow Thymus :thymic stromal cells(TSC) thymocytes T cell (αβ+ ) monocytes,macrophage,TDC :corteximmature thymocytes madullamature thymocytes M248。,TDC :It is the site of T cell maturation。 It determines the specificity of the TCR expressed on the T cells released to periphery thymus gland spleen 1. adult spleen:13*8cm 180250g 2. the white pulp:lymphoid cells the red pulp venous sinuses cellular cords :a reservoiv for platelets, erythrocytes and granulocytes。 destroy the Ag,aged platelets spleen Downloaded from: StudentConsult (on 1 June 2022 02:08 PM) 169。 2022 Elsevier lymph node 1. Human:210mm in diameter 2. round and kidney shaped 3. Consists of : Bcell area(cortex) Tcell area(paracortex) central medulla lymph node Mucosalassociated lymphoid tissue(MALT) lymphoid tissue the lamina propria and submucosal areas of the gastrointestinal,respiratory and genitourinary tracts. , appendix, Peyer’s patches cell IgA IEL Adaptive immune Mucosalassociated lymphoid tissue(MALT) Peyer’s patches M cell Lymphocyte recirculation 1. Lymphocytes leave the blood via highwalled endothelium of the postcapillary venules 2. Lymphocyte trafficking exposes antigen to a large number of lymphocytes Lymphocyte recirculation
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