immuneevasionofneisseriagonorrhoeae-資料下載頁
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【導讀】infection?T.Chen,R.Belland,J.Wilson,andJ.Swanson*.1995.J.Exp.Med.182:511-517.T.Chen,J.Swanson,J.Wilson,andR.Belland*.1995.J.Exp.Med.185:1557-1564.CEACAM3,(CGM1a,T.Chen*,S.Bolland,I.Chen,J.Parker,M.Pantelic,F.Grunert,andW.T.Chen*,S.Bolland,I.Chen,J.Parker,M.Pantelic,F.Grunert,andW.
【正文】 10 . 0204060801 0 01 2 01 3 6 . 4S[ C A + + ] 1 . 9 50 1 0 0 1 5 0 2 0 0 2 5 0 3 0 4 . 00 . 4204060801 0 01 2 01 4 01 6 01 7 3 . 7S[ C A + + ] Y459 is Essential for Inhibiting Ca++ Influx Fc(RIIBBGPa Fc(RIIBBGPaY459F Fc(RIIBBGPaY486F Fc(RIIBBGPaY459/486F A A A A I I I I Hypothesis: The interactions of GC with CEACAM on neutrophils （ 白血球 ） or B cells shape host responses. No. bacteria/well 102 Cell Death %02 04 06 08 01 0 0DT40CEACAM3Y196FY207FY196F/ Y207FC o n t r o lO p a GCO p a I GCphagocytosis cell death CEACAM3 (CD66d) Controls Cell Death. 陽性信號傳遞導致細胞死亡 Human Ig (181。g/ml) GC Inhibits Antibody Production by Primary Human B Cells 陰性的信號傳遞抑制 抗體產(chǎn)生 Neisseria gonorrhoeae inhibits host responses of CEACAMexpressing host cells through either activating or inhibitory signal transduction. Summary: 奈氏淋球菌借助了人體的陰性 /陽性的信號轉導過程，抑制了人體的免疫反應
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