[計(jì)算機(jī)]第3章補(bǔ)體系統(tǒng)-資料下載頁(yè)
2025-03-22 08:53本頁(yè)面
【正文】 of the microanism allowing for opsonization (enhanced attachment). C 5 aP o l y m o r p h sr e s p i r a t o r y b u r s tC 3 b R e x p r e s s i o n M a s t C e l l s. . . . . .................d e g r a n u l a t i o n a n a p h y l a t o x i n s m e d i a t o r sc h e m o t a c t i c p e p t i d e i n c r e a s e s v a s c u l a r p e r m e a b i l i t yC 3 b B bm i c r o b eC 3 bt i s s u e i n v a s i o no p s o n i s a t i o nC 3 aplement recognition molecules and receptors ? CR1 (CD35) mono/macs, PMN, lymphocytes, RBC C3b/4b phagocytosis ? CR2 (CD21) Bcells, FDC iC3b, C3d augments B cell activation ? CR3 (CD11b/18) mono/macs, PMN, NK iC3b, LPS adhesion, clearance ? CRP Ca++ dependent C1q binding, activates classical p, phagocytosis, apoptosis plement : structure and function Initiating pathways: ? classical pathway ? mannanbinding lectin pathway ? alternative pathway Effector pathway ? C3a, C4a, C5a inflammatory cell chemotaxis, mastcell degran ? C3b opsonin via C3bR, solubilisation of ic ? C5bC8, C9 membrane attack plex cell lysis Regulatory proteins ? control the amplification cascade ? short enzyme half life, Regulatory proteins C 3 bBbD A FC R 1 / M C PB r e a k d o w n o f C 3 c o n v e r ta s ePI GN O R M A LM e m b r a n e B o u n d R e g u l a to r sD e c a y A c c e l e r a ti n g F a c to rC o m p l e m e n t R e c e p to r IM e m b r a n e C o F a c to r Pr o te i nC 1 qC 1 r C 1 sC 4 aC 4 bC 4 aC 4 bM i c ro b eI o n i c b o n ds t a b i l i s e sC a + +C 1 e s t e ra s e I n h i b i t o rh e re d i t a ry a n g i o e d e m aC4c o v a l e n tAnaphylaxis laryngeal oedema C 1 qC 1 r C 1 sM i c r o b eC 2 bC2C 2 aC 4 bM g + +F a c to r IC 4 b pC 4 dC 4 bC 2 aC 3 bC 3 aC3C 3 C o n v e r t a s e( S e r i n e p r o t e a s e )U n s ta b l eC R 1Ic o fa c to rD A FC 2 aC 5 bC6C7C8C9C9C8L YSI SM EM B R A N E A T T A C K C O M PL EX2 . H o m o l o g o u s R e s t r i c t i o n F a c t o r H R F( C 8 B i n d i n g P r o t e i n )1 . M A C I n h i b i t o r y f a c t o rD e f i c i e n c y o f M A C ( t y p e I I I ), C 8 BP a n d D A F ( t y p e I I )E L y s i s a n a e m i aA l t e rn a t i v e Pa t h w a yR e g u l a t o rs F a c t o r IC o m p e te s w i th fa c to r B .F o r m s c o m p l e x s u s c e p ti b l e to F a c to r IC 3 b I n a c t i v a t o rC 4 bC 2 aC 3 bC 3 aC3C 3 C o n v e r t a s e( S e r i n e p r o t e a s e )U n s t a b l eC 2 aBiological consequence of plement activation ? Cell lysis ? Opsonization and phagocytosis ? Viral neutralization ? Inflammation ? Regulation of cells ? Clearance of immune plex
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