【醫(yī)學(xué)課件】糖尿病高危igt人群的干預(yù)ppt課件-資料下載頁
2025-01-15 21:04本頁面
【正文】 ith higher degrees of insulin resistance the lifestyle change alone is less effective in preventing DM and some additional intervention such as metformin may be needed. Diabetes Prevention Program (USA) 0CONTROLS METFORMIN LIFESTYLE 3000IGT involved ,followup years,2021 presented 58↓ 31% ↓ STOP NIDDM 051015202530354045CONTROLS ACRBOSE 1418 IGT involved, followup 3 years,2021 presented 33%↓ Incidence of Diabetes in Pharmacological intervention group of IGT in China (1997~2021) 2024681012controls Metformin AcarboseIncidence ofDM77% ↓ 88% ↓ tid 50mg tid Incidence of Diabetes in Pharmacological intervention group of IGT in China (Yuexin Wang ,3 years) 02468101214controlsn=58Acarbosen=58Incidence of DM69% ↓ 50mg TID Pharmacological interventions with Acarbose or Metformin could reduce the risk of worsening to diabetes by 60~80% in Chinese subjects with IGT. Intervention with Acarbose seems more effective in Chinese than that in Westerns SUMMARY How To Increase Effectiveness and Reduce Cost? …… STRATEGY OF THE INTERVENTION Incidence/pys Reduction of DM in peoples with IGT stratified by INSSEN and secretion 4 9 % 4 2 % 3 1 % 2 7 %G1 IAI FI/FG G2 IAI FI/FGG3 IAI FI/FG G4 IAI FI/FGG 4 G3 G2 G1 藥物預(yù)防的有效性 DPP 二甲雙呱 對年輕肥胖者更有效 2544 44% 4559 31% 60 11% BMI 2230 3% 3035 16% 35 53% 藥物預(yù)防的有效性 DPP 方式干預(yù) 與二甲雙呱療效比較 2544 8% 4559 41% 60 69% BMI 2230 63% 3035 53% 35 4% 藥物預(yù)防的有效性 DPP 二甲雙呱 的有效性 PG2H(mg/dl) 140153 41% 154172 38% 173199 26% ? Targeting Insulin resistance or insulin insufficiency? Prevent diabetes or reverse to normal glucose tolerance? How to Screen…? One Step or Two Steps? How can we have IGT clinical trials Get Out Of the Ivory Tower ? 讓臨床試驗走出神殿 任重而道遠(yuǎn) THANK YOU
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