抗體的選擇和保存指南-資料下載頁
2025-01-06 14:18本頁面
【正文】 tion, and DNA binding regions, and a carboxy terminal transactivation domain. Serines 529 and 536 in the transactivation domain of RelA/p65 are phosphorylated in response to several stimuli including phorbol ester, IL1 alpha and TNF alpha as mediated by IkB kinase and p38 MAPK. Serine 529 is located in a negatively charged region (amino acids 422540) that is phosphorylated in response to phorbol myristate acetate plus calcium ionophore activation. Phosphorylation of serines 529 and 536 is critical for RelA/p65 transcriptional activity. Activated NFkB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFkB has been associated with a number of inflammatory diseases while persistent inhibition of NFkB leads to inappropriate immune cell development or delayed cell growth. Alternative names for NFkB p105 / p50 antibody [E381] (ab32360) Database links The links below go to external sites and will open in a new browser window Entrez Gene 4790 (Human) 18033 (Mouse) 81736 (Rat) GeneCard GC04P103880 (Human) Omim 164011 (Human) SwissProt P19838 (Human) P25799 (Mouse) Q63369 (Rat) Unigene 431926 (Human) Raised in Rabbit Clonality Monoclonal Clone number E381 Isotype IgG Purity Protein A purified Storage buffer Preservative: % Sodium Azide Constituents: 40% Glycerol, % BSA, Sodium chloride, 50mM Tris glycine. pH Material safety datasheets (MSDS) for this product: Form Liquid Storage instructions Shipped at 4176。C. Upon delivery aliquot and store at 20176。C. Avoid freeze / thaw cycles.
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