腎上腺素受體激動藥-資料下載頁
2024-10-19 17:32本頁面
【正文】 ? Oxymetazoline, apraclondine ? Clonidine, methyldopa βR agonist ? β1 and β2R agonist ? Isoprenaline: lower selectivity to both β1 and β2R, little effect on αR pharmacological Effects ? heart: positive inotropic effect ,increase the heart rate and conduction, cardiac output increase ? blood vessels : reduction of peripheral vascular resistance in skeletal muscle, renal and mesenteric vascular beds。 pharmacological Effects ? blood pressure: diastolic blood pressure falls , systolic blood pressure increase ? Relax both bronchial and gastrointestinal smooth muscle ? Metabolic effects pharmacokiics ? Resistance to MAO ? less be uptaken ? aerosol Clinical uses ? Bronchial asthma ? Atrioventricular block ? Cardiac arrest ? Shock Adverse Effects ? palpitation。 dizziness ? overdosage by inhalation can produce fatal ventricular arrhythmia ? Contraindication: myocarditis ,coronary heart disease。 hyperthyroidism β1R agonist ? β1 reaction is more potent thanβ2 reaction ? Dobutamine Dobutamine ? direct β1R agonist ? greater inotropic effect than chronotropic effect ? little effects on peripheral vascular resistance. ? Clinical uses: improve myocardial function in congestive heart failure . Adverse reactions ? BP , palpitation ? Contraindication: IHSS, atrial fibrillation β2R agonist ? bronchial asthma
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