代表講稿2-doripenem-anewbroa(編輯修改稿)
2025-03-11 14:30 本頁面
【文章內(nèi)容簡介】 ith other betalactam antibiotics : bining with bacterial penicillinbinding protein (PBPs) inhibites bacterial cell wall synthesis. ? Doripenem has strong antibacterial activity and stability against the vast majority of betalactamase and kidney dehydrogenation endopeptidase (DHP) 1. 1. Antibacterial activity against G+ ? Methicillin susceptible staphylococcus aureus, Staphylococcus epidermidis :slightly lower than imipenem, stronger than meropenem and biapenem ? Methicillinresistant Staphylococcus aureus, Staphylococcus epidermidis :2 ~ 4 times stronger than other control drugs ? Strongest antibacterial activity to Streptococcus pyogenes ? Penicillin susceptible Streptococcus pneumoniae: similar to imipenem ,stronger than meropenem and biapenem ? Penicillinresistant Streptococcus pneumoniae: identical with others ? Enterococcus faecalis: slightly lower than imipenem, strong in contrast to other drugs Comparison of the MIC90(μg/ml) for doripenem and three other carbapenems tested against Grampositive pathogens Strains (NO.) Doripenem Imipenem Meropenem Biapenem Methicillin susceptible staphylococcus aureus(30) Methicillinresistant Staphylococcus aureus(30) 16 32 32 64 Methicillin susceptible Staphylococcus epidermidis(46) Methicillin resistant Staphylococcus epidermidis(27) 32 128 64 128 Streptococcus pyogenes(42) ≤ Penicillin susceptible Streptococcus pneumoniae(25) Penicillinresistant Streptococcus pneumoniae(25) Enterococcus faecalis(26) 4 1 8 8 MIC90 : MIC at which 90% of the strains were inhibited 2. Antibacterial activity against G Doripenem is sensitive to many G bacteria, such as: E. coli Klebsiella pneumoniae (肺炎克雷白桿菌） Enterobacteriaceae （腸桿菌） Proteus mirabilis （奇異變形桿菌） Proteus vulgaris （普通變形桿菌） Haemophilus influenza （流感嗜血桿菌） P. aeruginosa （銅綠假單胞菌） Comparison of the MIC90(μg/ml) for doripenem and three other carbapenems tested against Gramnegative pathogens Strains (NO.) Doripenem Imipenem Meropenem Biapenem E. Coli (30) Klebsiella pneumoniae(30) Aerobacter cloacae(
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