醫(yī)療機(jī)構(gòu)開展基因?qū)騻€(gè)體化給藥的機(jī)遇和瓶頸(編輯修改稿)
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【文章內(nèi)容簡(jiǎn)介】 in doseWadelius et al. (200 9) Blood 113: 784792p CYP2C9p VKORC1, Vitamin K epoxide reductasep Other candidate genes (GGCX, APOE ) p Effect of bining CYP2C9 and VKORC1p Nongeic factors (age, gender)Warfarin Pharmacogeicsvariable valueGender female n(%) 80(58%)Ageyears 69177。12Indication for treatment n(%)Atrial fibrillation of flutter 61(%) Thrombosis or embolus 33(%)Pulmonary embolism 28(%)valve replacement 16(%)others 9(%)Target of INR 123(88%) 16(12%)Retrospective Study in collaboration with Peking University Third Hospital (n=139)Demographic characteristicGene/SNP N allele (%) genotype(%)W M W/W W/M M/MVKORC1 rs9923231 182 rs9934438 182 rs7294 182 CYP2C9 rs1799853 181 0 rs1057910 182 0GGCX rs6996644 182 APOE rs429358 180 rs7412 179 The frequencies of allelic and genotype in VKORC1, CYP2C9, GGCX, APOEGene/dilotype N n Frequencie (%)CYP2C9 181 CCAA 166 CCAC 14 TCAA 1 VKORC1 182 AATTAA 149 AACTAA 5 AGCTAA 1 AGCTGA 26 GGCCGG 1 APOE 179 TTCC 130 TTCT 19 TCTT 1 TCTC 3 TCCC 23 CCCC 1 The frequencies of dilotype in VKORC1, CYP2C9 and APOE Warfarin mean daliy dose P valueW/W W/M+M/MVKORC1 rs9923231 177。 177。 ＜ rs9934438 177。 177。 ＜ rs7294 177。 177。 ＜ CYP2C9 rs1057910 177。 177。 APOE rs429358 177。 177。 rs7412 177。 177。 A association between polygeic SNPs and warfarin dose (1)A as
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