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g ?Partnerships ?Intervention development ?Phase III trials ?Regulatory approval ?Partnerships ?Health services research to support dissemination and adoption ?To munity providers ?To patients and public ?Adoption of advance by providers, patients, and public ?Payment mechanisms to enable adoption Source: National Cancer Institute Translational Medicine ? Translate the success in genomic medicine into clinical applications ? Evidencebased medicine develop rationale and theory for drug design and therapeutic intervention ? Develop personal medicine and preventive medicine Translational Medicine ? Translational Research hot spot – Genomic and gene diagnosis and treatment基因組研究及基因診斷治療 – Phase I trial for drugs 藥物一期臨床試驗 – Genomic Pharmocology and personalized medicine 基因組藥理學(xué)與個體化醫(yī)學(xué) – Biomarks 生物標(biāo)記物 – Signal transducting pathway and clinical applications 信號傳導(dǎo)通路的研究及其臨床應(yīng)用 – Stem cell干細胞 Translational Medicine ? The heart of translational research resides in Phase I trials where novel treatments are : – tested for feasibility and toxicity – preparation for a Phase II trial in which therapeutic effectiveness is tested 187。 Marincola, FM 187。 Translational Medicine: A two w ay road, JTM, 2022 Clinical Research Training Program ? Computer Skills ? Clinical Research Methods ? Biostatistics: Statistical Approach in ? Clinical Research ? Measurements in Clinical Research ? Ethics and Regulations of Clinical ? Research ? Research Design and Development ? Costeffectiveness Analysis ? Regression and ANOVA ? Logistic Regression ? Clinical Trials The process of Translation ? Choose a research topic related to your clinical practice Early study on nitric oxide Synthase Uses for a cloned gene ? Homology parison ? Quantitate gene expression ? Chromosomal mapping ? De