bipolardisorderindsm-iv-centerforaddictions雙相情感障礙在dsm-iv中心為成癮(編輯修改稿)
2025-02-08 07:41 本頁面
【文章內(nèi)容簡介】 s in 60% to 70% of cases Firstdegree relatives may have increased rates of BPD I, BPD II, and MDD Recurrent in 90% of cases Firstdegree relatives have increased rates of BPD I, BPD II, and MDD Course Familial pattern Epidemiology ? Peak age of onset: adolescence through early 20s – Onset of first manic episode after age 40 years is “red flag” to consider substance use or general medical condition ? Seasonal variation – Depression more mon in spring and autumn – Mania more mon in summer Diagnostic Dilemmas: Unipolar Versus Bipolar No evidence of hypomania, cyclothymia, hyperthymic personality, or family history of BPD ?1 manic episode Recurrent major depression with hypomania and/or cyclothymic temperament Recurrent major depression without spontaneous hypomania but often with hyperthymic temperament and/or family history of BPD Unipolar BPD I BPD II BPD NOS Etiology Heritability ? Evidence for heritability is much stronger for bipolar than for unipolar disorders ? Specific geic association has not been consistently replicated EVIDENCE FOR HERITABILITY OF BIPOLAR DISORDER ? Family Studies First degree relatives are 8 to 18 times more likely to have Bipolar I ? 2 to 10 times to have MDD. ? Risk is 25% if one parent has illness, and 50% to 75% with both parents affected FAMILY STUD
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