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s. HPS Collaborative Group. Lancet 2021。 360 :7 208。 22. HPS: Heart Protection Study RESULTS ? Allcause mortality in simvastatin group significantly reduced pared with placebo ( vs. %, P)。 reduction was attributed largely to significant reduction in coronary death: —Other vascular death reduced but with marginal significance —Nonvascular death reduced but not significantly ? First major vascular event rate significantly reduced, as were the individual event rates (fatal/nonfatal MI, fatal/nonfatal stroke, and revascularization) ? No difference in new cancers ( vs %, rate ratio , P=) except nonmelanoma skin cancer ( vs %) ? No difference in withdrawal due to myopathy (% in both groups) HPS: He