慢性病的環(huán)境因素分析(存儲(chǔ)版)
【正文】 Fructose Lead, other heavy metals Some Pesticides Altered Pathways Environment Drives Chronic Disease Environmental Factors Chronic Disease SocioEconomic Stress Depression, poverty, violence, inadequate health care Socioeconomic, Psychosocial Stressors ? Stress, depression? risk for CVD, AD Sesso, Kario, Ownby ? People with lower SE status are at risk for exposure to multiple environmental hazards? ↑damage. – Lead + stress ? ↑c(diǎn)ognitive impairment Glass 2022 – Lead + air pollution ?↑CV autonomic dysfunction Park 2022 People who live in neighborhoods that lack social cohesion, sidewalks, or safety limit their exercise and have an increased risk of depression and possibly obesity. Berke EM 07, Molnar BE 04 Effects of the Built Environment on Health Insulin signaling ? ↑ blood sugar ? ↑ artery disease ? ↑ triglycerides Inflammation Oxidative stress Environmental Factors Disrupt Insulin Signaling, Drive Inflammatory Metabolism Obesity Endocrine Disruptors BPA, dioxins, PCBs, some pesticides Inactivity Saturated fat High Glycemic Carbohydrates Air Pollution ↓Antioxidants ↓Omega3 Fructose Lead, other heavy metals Some Pesticides Stress Multiple Factors Interact to Influence Health amp。 Ben Rohrer Primary authors of this presentation: Jill Stein MD, Ted Schettler MD, MPH Contributing Authors: Maye Thompson RN, PhD, Marybeth Palmigiano MPH, Maria Valenti. Illustrations by: Stephen Burdick Design Permission is granted to use this presentation or individual slides with proper acknowledgement and cited as from Environmental Threats to Healthy Aging by Stein, Schettler et al. The authors of the presentation do not authorize changes, and are not responsible for the accuracy of material if changes have been made. For more information contact: Greater Boston Physicians for Social Responsibility Additional References For Mediterranean Diet Slide 28 Additional Notes What’s Novel in the Western Diet? Slide 22 。 insulin resistance at low levels (animals). AlansoMagdelena 2022, Wada 2022 ? 3fold ↑ Cardiovascular disease. Lang 2022 ? 2fold ↑ Insulin Resistance. Lang 2022 Bisphenol A polycarbonate Insulin signaling ? ↑ blood sugar ? ↑ artery disease ? ↑ triglycerides Inflammation Oxidative stress Environmental Factors Disrupt Insulin Signaling, Drive Inflammatory Metabolism Endocrine Disruptors BPA, dioxins, PCBs, some pesticides Saturated fat High Glycemic Carbohydrates Air Pollution ↓Antioxidants ↓Omega3 Fructose Some Pesticides Lead, other heavy metals Altered Pathways Environment Drives Chronic Disease Environmental Factors Chronic Disease Built Environment Physical Activity Health Benefits of Physical Activity ? Reduced ongoing levels of oxidative stress and inflammatory burden. Brooks 2022, Attipoe 2022 ? Inversely associated with the risks of Alzheimer’s/dementia and cognitive decline. Rovio 2022 ? Subjects at risk for AD who walked 150 min. per week showed improvements in cognition while the control group showed no change from baseline at yrs. Lautenschlager 2022 Increasing physical activity at any age improves physical and emotional wellbeing. ? Walkable Cities Projects ? Community Gardens ?Farmer’s Markets ? Rails to Trails Livable Communities Enhance Healthy Aging Cuba lost fossil fuels? ↑biking, walking, local plantbased food ↑physical activity 50% ↓obesity 50% ↓mortality: DM 51
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