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uses include ingesting expired tetracyclines which damage proximal tubule, and as a side effect of tenofovir. ?Lead poisoning also leads to Fanconi syndrome. ?Multiple myeloma or monoclonal gammopathy of undetermined significance can also cause the condition. ?Additionally, Fanconi Syndrome can develop as a secondary or tertiary effect of certain autoimmune disorders. 范可尼綜合征 ?Wilson病或重金屬中毒可通過促進(jìn)毒物排泄,遺傳代謝病通過飲食管理減少代謝毒性物質(zhì)沉積,減輕對腎小管的損害。Fanconi Syndrome WernickeKorsakoff Syndrome and Side Effect of Adefovir Contents ?患者病情特點(diǎn) ?范可尼綜合征 ?韋尼克 科薩科夫綜合征 ?阿德福韋不良反應(yīng) 患者病情特點(diǎn) ?女性, 61歲 ?乙肝肝硬化病史多年,口服阿德福韋 8年 LAM→LAM+ADV→ETV Qd po ?因意識障礙、視力下降、聽力下降 4天就診 ?間斷譫妄、幻視、幻聽、耳鳴、短時記憶障礙 患者病情特點(diǎn) 查體: ?精神差,應(yīng)答切題,反應(yīng)略遲緩; ?計算力正常,定向力正常; ?眼球運(yùn)動正常,無眼震,視力下降,聽力下降; ?腦膜刺激征陰性,巴氏征可疑陽性,腱反射正常 患者病情特點(diǎn) 影像學(xué)檢查: ?顱腦 MRI:中腦導(dǎo)水管周圍可見對稱性斑片狀長 T1 長 T2信號,考慮酒精性腦病, MRA、 DWI未見異常 ?腰椎骨盆 X線片:腰 34椎體輕度壓扁,骨盆