【正文】
rosomal CYPs: CYP17A CYP19A CYP21A1 Six P450 enzymes are involved in steroidogenesis In human adrenal P450s been intensively studied in steroid synthesis. In bacteria, the P450s are used in catabolic pathways for the production of steroids, bioactive lipids and chiral synthons. ? Microbial CYPs Actinomycetes Mycobacterium smegmatis (39 P450s) Mycobacterium tuberculosis (20 P450s) Streptomyces coelicolor (18 P450s) ? 甾體羥化酶大都是細(xì)胞色素 P450依賴型單加氧酶,屬于末端氧化酶,能將一摩爾分子氧引入底物,通過 NADPH遞氫,完成羥化反應(yīng)。細(xì)胞色素 P450酶系 孫 婉菊 2022年 12月 17日 P450酶系概述 ? 細(xì)胞色素 P450單加氧酶系 (cytochrome P450 monooxygenases, P450s) : NAD(P)H細(xì)胞色素 P450還原酶 (CPR) 細(xì)胞色素 P450單加氧酶 (CYP) 2個組分均通過疏水的膜結(jié)合錨點結(jié)合在微粒