1218細胞色素p450酶系-文庫吧
2025-07-10 14:14 本頁面
【正文】 d in steroidogenesis In human adrenal P450s been intensively studied in steroid synthesis. In bacteria, the P450s are used in catabolic pathways for the production of steroids, bioactive lipids and chiral synthons. ? Microbial CYPs Actinomycetes Mycobacterium smegmatis (39 P450s) Mycobacterium tuberculosis (20 P450s) Streptomyces coelicolor (18 P450s) ? 甾體羥化酶大都是細胞色素 P450依賴型單加氧酶，屬于末端氧化酶，能將一摩爾分子氧引入底物，通過 NADPH遞氫，完成羥化反應(yīng)。 RH + NADPH + O2 ROH + NADP+ + OH Steroidogenesis ? 細胞色素 P450酶系羥化反應(yīng)主要 有： 9α羥化、 11α羥化、 11β羥化、 16α羥化、 17α羥化和 19α羥化等。 ? 甾體化合物分子中 11羥基的引入在甾體藥物化學中占極為重要的地位。 Towards Preparative Scale Steroid Hydroxylation with Cytochrome P450 Monooxygenase CYP106A2 from Bacillus
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