全球哮喘處理和預(yù)防策略課件(文件)
【正文】 白沉積增加 基底膜增厚 血管新生,平滑肌 功能障礙,氣道 炎癥,氣道重塑,哮喘病理生理學(xué),Johnson. Curr Allergy Clin Immunol 2010,氣道炎癥,平滑肌 功能障礙,氣道 重塑,沙美特羅 LABA,氟替卡松 ICS,支氣管狹窄 氣道高反應(yīng)性 增生 炎癥介質(zhì)釋放,炎癥細(xì)胞浸潤/活化 粘膜水腫 細(xì)胞的增殖 上皮損傷 基底膜增厚,哮喘加重,正常,哮喘加重時(shí),上皮細(xì)胞,黏膜下層,平滑肌,氣道腔,IgE,ICAM1/3,IL1,CD4,antigen presentation,IL12,CD8,MCP3,IL5,IL6,NCF,MIP1?,LTB4,SCF,IL3,IL14,tryptase,GMCSF,LTC4,RANTES,TNF?,IL8,eotaxin,IL13,LTE4,IFN?,PGD2,histamine,IL1,PAF,chemokines,LTD4,IL4,GMCSF,Ckit,IL6,Th2,SCF,GMCSF,IL13,TNF?,IL1?,IgE,IL10,IL4,IL3,IL5,IL6,Th1,TNF?,IL2,IFN?,Th0,GMCSF,IL2,IFN?,IL4,histamine,cytokines,LTC4,LTD4,LTE4,IL13,IL4,PGS,IgE,GMCSF,PAF,protease,IL6,IL8,TNF?,TGF?1,PAF,LTD4,TXA2,IL1?,IL6,MPO,O species,BIP,IL8,LTB4,LTC4,adhesion molecules,GMCSF,ICAM1,IL4,Lselectin,PGS,TNF?,ET2,ET1,IL1,GCSF,IL6,TGF?,PDGF,GMCSF,IL1,IL6,MIP1,RANTES,COLLAGEN I, II, V,IL8,MCP1,PGE2,collagenase,ICAM1,IL11,SCF,VCAM1,LTC4,MCP3,IL4,IL6,IL10,LTD4,O2,PDGFB,ECP,IL5,IL8,HBEGF,TGF,GMCSF,TXB2,RANTES,TNF?,IL3,IL1?,EDP,MBP,15HETE,IL2,PAF,0 species,IFN?,IL13,MIP1?,CR3,EDN,ICAM1,MCP2,MCP1,IL?,IL5,MCP3,MIP1?,iNOS,PAF,IL10,LTB4,EAF,IL1?,TNF?,IL6,IL1,eotaxin,PGE2,IL12,IFN?,RANTES,IL3,GMCSF,0 species,IL8,protease,MCP1,IL5,IL3,15LD,SLPI,NEP,COX2,iNOS,15LT5,PGF2?,PGE2,IGFI,CGRP,FGF,IL16,IL8,CPLA2,adhesion molecules,GRO?,GMCSF,MCP2,RANTES,IL1?,TNF?,IL6,IL11,ET1,VIP,9/13 HODE,15HETE,eotaxin,IL17,PDGF,IL10,MIP1?,ICAM1,RANTES,cytokines,eotaxin,GMCSF,IL8,MCP1,PGE2,MCP2,MCP3,MCP3,MIP1?,NO,IL1?,TNF?,eotaxin,PGE2,IFN?,RANTES,IL3,0 species,IL2,TXA2,IL8,cytokines,IL6,IL10,IL12,LTB4,LTC4,ICAM1,GCSF,IFN
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