吲哚美辛緩釋片的處方研究與制備(已修改)
2025-07-08 08:38 本頁面
【正文】 黃山學院本科畢業(yè)論文 本科生畢業(yè)論文（設計）吲哚美辛緩釋片的處方研究與制備目 錄中文摘要………………………………………………………………………………2外文摘要…………………………………………………………………………3引言……………………………………………………………………………………41 實驗部分……………………………………………………………………………6 儀器與試劑……………………………………………………………………6 標準曲線的建立………………………………………………………………7 緩釋片的制備……………………………………………………………7 溶液的配制………………………………………………………………7 最大吸收波長的選擇……………………………………………………7 標準曲線的繪制…………………………………………………………7…………………………………………………………8 精密度實驗………………………………………………………………9 回收率實驗………………………………………………………………9 吲哚美辛緩釋片的處方擬定與制備………………………………………10 ……………………………………………………………10 …………………………………………………………102 實驗結果分析與小結……………………………………………………………11 釋放過程考察………………………………………………………………11 ……………………………………………………………12 …………………………………………………………………133 總結………………………………………………………………………………13參考文獻……………………………………………………………………………15致謝…………………………………………………………………………………16吲哚美辛緩釋片的處方研究與制備摘 要：本文主要目的是為了改善吲哚美辛普通口服制劑的釋藥過程，減少毒副作用，提高患者順應性，將制成吲哚美辛緩釋片。以親水性羥丙甲基纖維素作為骨架材料，采用濕法制粒壓片制得，然后通過紫外分光光度計在320nm波長下考察其體外釋放度，進行釋藥機制的研究。最后通過平行試驗測定各處方在2h、6h、12h的累積釋藥量以及對其釋藥曲線的考察，經(jīng)過處方篩選，最終優(yōu)選得到最佳處方。結果表明采用處方5所制備的緩釋片具有良好的緩釋效果，而且制備過程操作簡單。關鍵詞：吲哚美辛；緩釋骨架片；釋放度；處方篩選Preparation and invitro Release of Indomethacin Sustained Release TabletsBa XiaojingDirector：Ke Zhongcheng（College of Chemistry and Chemical Engineering, Huangshan University, Huangshan, Anhui, 245041）Abstract：The main purpose of this paper is to improve oral indomethacin mon preparation process of drug release, reduce toxicity, the patients improve pliance, and will be made into Indomethacin Sustainedrelease tables. The wathersoluble hydrophilic matrix HPMC(K4) was used to prepare sustaindrelease tablets by the wet granule pression technique. The content of the major drug was determined by UV spectrophotometry at 320nm, the release mechanic was studied by determining the dissolution. Finally through the parallel tests determine the prescription in 2 h, 6 h, 12 h the accumulation of the drug release and the curve of drug release of investigation, after screening eventually get the best prescription optimization prescription. The result showed that the Indomethacin Sustainedrelease tables which were perpared by the formula of 5 was good in release effect,
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