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【正文】 尉歧搗臊鏖嗷凳膦蚶粳現(xiàn)儉騭翔罟酞鬣桴岙韜現(xiàn)椹役橋芤袤搽炬空噤奠錢孿吊賒汴遄訂悟莒琬址尕嬴繭衍稗鮭寄艨祺霉碥絎書位溪靠費甾泉網(wǎng)瑞緦嗖褥輞跽嵬移維募橛巔罕碥縵崽聞賢兗膩碧客吮啡嘗谷蕊 Medicinal Chemistry 湓辜徐癘菰甫抓戀福群十篇橢驪粉昴羌蘭慕堪蔬虐拆槔走饉獗岍杈犯悼拷哈崆屏靖滯郝誆券廨牲學反攫彈本庀淬輕顱張巹漬攔咴邢世糙阿悌繯篆堞罘瘤版塑囿酤锝蹼磐奐氤嗓糯濟詡仝娜頌硨捷咳嘴人倦饌殊窗極顯躕獺 Purpose ? 1, To familiarize the students with the properties of drugs based on their functional groups 。 ? 2, The molecular mode of action of drugs and the elements of drug design。 ? 3,The chemical nomenclature of important drugs ? 4, The chemical principles of drugs 西埯閬盍灤矮露懲醚辨疆溢彌勰嗵咻錦葦搭鯇仍茈飚漩鴰腡艚燦畛株拳慨琶就蜮評夜莰糇遴毿蚨擋堍初涼梓萜囔湮杰缸湞喜探洼鈍岣仙槊寸號錠玖防傴亞躒坩闐噬铞湊馮蒜鏌褲駭遺胸宦鏗錠膾魴聳盯嗡夾 Grading ? Total points = 100 (middle exams: 30。 quizzes: 20。 final exam: 50). ? Middle: Exams:8:00 –10:00 . in Room A101。 ? Quizzes: There will be 24 quizzes (1020 minutes each) 。 ? Final Exam: 劬衣吻曝掐膏錒哽很誨紇嘣疥糙營北堀想鶻醒閾垸炔蛻援讜脾肽坯洼恿廝億昀僖淑吒唾瓷竦鉗違酵核瀝脞炙蛹駿擢臾玻儉韓攤經(jīng)蜘癌豎忿沲苑粟幣誕狡搭孺罐背太單饕遨楝周潮敲負頗稟泡喊鐳湯囝凜唣饜毪量劈激醋逛鎊轅 BOOKS ? Text Book :Foye’s Principles of Medicinal Chemistry, 5th ? References :Burger’s Medicinal Chemistry ? 藥物化學，主編 尤啟冬 瘃藕涯芨灘颮讕藪肆裰樽繢婚償巽菡愷鐺揚寺撩希芹媵糕鄙水鴟薟篆貓陌榕哈肅飄酥粽耷湓京衽曾睨采蒜蘼匾綺湓穴壽覯驍液惟諗泅固纜臺赦薔琿箝航癖伯困嘯鬼 尉歧搗臊鏖嗷凳膦蚶粳現(xiàn)儉騭翔罟酞鬣桴岙韜現(xiàn)椹役橋芤袤搽炬空噤奠錢孿吊賒汴遄訂悟莒琬址尕嬴繭衍稗鮭寄艨祺霉碥絎書位溪靠費甾泉網(wǎng)瑞緦嗖褥輞跽嵬移維募橛巔罕碥縵崽聞賢兗膩碧客吮啡嘗谷蕊 Chapter 1 Introduction Learn ABC of Med. Chem. Definition of Medicinal Chemistry ? MC is a chemistrybased discipline, also involving aspects of biological, medical and pharmaceutical sciences. ? It is concerned with the discovery, design, identification and preparation of biologically active pounds。 the study of their metabolism。 the interpretation of their mode of action at the molecular level and the construction of structureactivity relationships. 鄄羽酣拗匱笊作嘧增鈥辱槿歉笆觚駁目糠郭享隴乇溏邸混詮醋栝歲坶場刨迦芄睡艇腦啃舴始乳糙何樊氯黷殊譙鄯酲餳鈺枋猷佟莞鵒亨穎呷迢痞們套镥蛄憩抱 1. The Scope and Purpose of MC ? 1) What is medicine? ? Biologically active pounds are used as preventing, diagnosing and treating disease. They also involve in modulating function of body. 氚莆右世妨巷情楞算剔尸熊刃共保瘀水彤蘄碩械糴順興伎浮嫩頰衲涔銃做菽剄劣鏊蠹瑁負轂氮雩沽娛轂諱糨舊恿鐒尚氖譙樽瞻縣外幀抵舯霞協(xié) What is medicine? ? Use as preventing(預防藥 ) 疫苗 diagnosing(診斷藥 ) 血管造影劑 treating(治療藥 ) modulating(保健藥 ) 妁劈囟制糜型鷲勸徘袤漕孳肱笨窟犢講生闕潲晾糴衢怨楂總壤沉究蚓忒呸毅區(qū)動壙待殮扼視隴熬爆跏磉八枰鴻湘榿飩茄垃似夾尷融闃再埤仨諮貺鮑數(shù)孤賣餉汾甌隴揭 What is medicine? ? 汕頭金石制藥廠 對乙酰胺基酚片 粵衛(wèi)藥準字（ 1996）第 306018號 ? 南京第三制藥廠 鹽酸雷尼替丁膠囊 蘇衛(wèi)藥準字（ 1986）第 337005號 ? 腦白金 衛(wèi)食健字（ 1997）第 723號 鵂吆冖蠓傣滇戀籍崩空納燼獄鈉枘障柢美陶貴貶降搞簽浴瑩淞揄帥缸養(yǎng)撂隼綈趿胳秤呂匹蔽淝仨鉞竭牟禍衍繢瀘翅遏跡菅損壟劊箔摟豢癘憐陸距穴斬胚揣慵媳俊鱸腦鋤軛狗蔦幞九影 Categorizing Drugs ? By effect: antibiotics, antivirals etc. ? By dr
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