《臨床表現(xiàn)》ppt課件-文庫吧
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【正文】 sion HBeAg(+) →( )and antiHBe() →(+) ? HBcAg existing in the core of virion a marker of replication and infectivity AntiHBc IgM a marker of acute primary HBV infection AntiHBc IgG appeared in almost all HBV present and past infection host body ? HBVDNA the genome of HBV suggesting active virus replication and infectivity useful for diagnosis and evaluation of antiHBV therapy Hepatitis B Virus EtiologyHCV ? RNA virus, 6genotypes, mainly 1b in the country ? Molecular heterogeneity driven by high mutation rate usually proceed to chronic course ? AntiHCV IgM and IgG types antibody to HCV suggesting HCV infection ? HCVRNA the genome of HCV suggesting replication and infectivity of HCV useful for the diagnosis and evaluation of antivirus treatment EtiologyHDV ? An inplete RNA virus ? Causes hepatitis only patients with either acute(coinfection) or chronic (superinfection) hepatitis B ? HDVAg and antiHDV ? both the markers of HDV infection ? HDVRNA ? the genome of HDV ? a marker of existing HDV infection ? suggesting virus replication and infectivity EtiologyHEV Nonenveloped RNA virus Appeared in bile and feces, spreaded via feces No chronic carrier status observed AntiHEV IgM and IgG both appeared in acute infection useful for the diagnosis of HEV infection ? HEVRNA the genome of the virus suggesting existing of HEV infection not available for routine clinical diagnosis Epidemiology ? Source of infection Patients with acute or chronic viral hepatitis Carriers of hepatitis virus, particularly asymptomatic carriers ? Transmission Hepatitis A and E transmitted by the fecal oral route, waterborne and foodt
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