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【正文】 和原料一樣 ,試解釋之 . SN2 OO O HOO 2討論 : ⅰ 過氧化物的檢驗 :加入硫酸亞鐵和硫氰化鉀的 水溶液時 , 若出現(xiàn)紅色 ,則表明醚中有過氧化物 存在 (或對碘化鉀 淀粉試紙呈陽性 )。 ⅱ 過氧化物易爆 ,若有加入 5%的硫酸亞鐵 ,振搖 ,分層 , 干燥 ,蒸餾再用 . O*?*O HOH*（ Claisen ） O HN a HT H FO N aB rO**?*O H討論 :ⅰ 機理 :六員環(huán)過度態(tài) 。 ⅱ 重排到鄰位時 ,γ碳與芳環(huán)相連 ,當鄰位被占時 ,重排 到對位 ,則 α碳與芳環(huán)相連 。 Ludwig Claisen(18511930) Was born in Cologne, Germany, and received his . at the University of Bonn, studying under Augst Kekule. He never Married, but devoted himself throughout his life to anic chemistry. Among his positions, he was professor at the University of Bonn ,Owens College(Manchester), and the university of Munich, Aachen, Kiel, and Berlin. ⅲ 用于向芳環(huán)上引入烯丙基 。 ⅳ 舉例 : OC H 3H 3 C?H 3 C C H 3O H?O(1) O H(2) 167。 醚的制備 1 The Williamson Ether Synthesis O HN a HO N aH 3 C IT H FOC H 3討論 : ⅰ 機理 SN2。 ⅱ 鹵代烴為伯鹵 .叔鹵易消去 ,不能用于 The Williamson Ether Synthesis. ⅲ 用于簡單醚 ,混合醚 ,環(huán)醚 (分子內 )的制備 . ⅳ 舉例 : Alexander W. Williamson(18241904)was born in London, England, and received his . at the University Of Giessen in 1846. His ability to work in the laboratory was hampered by a childhood injury that caused the loss of an arm. From1849 untill1887,he was professor of chemistry at University College, London. OH O H 2 CH OH OO HO HC H 3 IA g 2 OOH 3 C O H 2 CH 3 C OH 3 C OO C H 3O C H 3(2) 選擇合適原料合成甲基叔丁基醚 . OC l H 3 C O N aO KH 3 C Iab(1) a路線中 ,叔鹵在醇鈉存在時 ,以消去為主 。 所以選擇 b. (3) 利用 Williamson 合成 ,從合適原料合成 1,2環(huán)氧丙烷 . H3C CHC H2H O B rH3C CHC H2O HB rN a O HH3C CHC H2
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