【正文】 hly Sensitive Search Strategy for identifying randomized trials in MEDLINE: sensitivity and precisionmaximizing version (2022 revision)。 PubMed format 1 randomized controlled trial [pt] 2 controlled clinical trial [pt] 3 randomized [tiab] 4 placebo [tiab] 5 clinical trials as topic [mesh: noexp] 6 randomly [tiab] 7 trial [ti] 8 1 or 2 or 3 or 4 or 5 or 6 or 7 9 animals [mh] not humans [mh] 10 8 not 9 注： [mesh: noexp] denotes a Medical Subject Heading (MeSH) term (not ‘exploded’ ) [ti] denotes a word in the title Evidencebased Medicine 中、英文數(shù)據(jù)庫(kù)簡(jiǎn)介 (5) Evidencebased Medicine （ Elsevier）推出的針對(duì)生物醫(yī)學(xué)和藥理學(xué)領(lǐng)域信息所提供的基于網(wǎng)絡(luò)的數(shù)據(jù)檢索服務(wù)的專(zhuān)業(yè)檢索引擎。 EMBASE（ 1974年以來(lái)）MEDLINE（ 1966年以來(lái)）的 1800多萬(wàn)條生物醫(yī)學(xué)記錄。檢出記錄不重復(fù)。 囊括了 70多個(gè)國(guó)家 /地區(qū)出版的 7,000多種刊物，覆蓋各種疾病和藥物信息，涵蓋有大量歐洲和亞洲醫(yī)學(xué)刊物 Evidencebased Medicine EMTREE EMTREE可在 EMBASE和 MEDLINE 之間檢索，可自動(dòng)進(jìn)行主題詞對(duì)照檢索。 EMTREE包含超過(guò) 語(yǔ)、 2萬(wàn)條同義詞（包括所有的 MeSH術(shù)語(yǔ)）配以17個(gè)核心的藥物 關(guān)聯(lián)詞 47個(gè)投藥途徑 關(guān)聯(lián)詞 和14個(gè)疾病 關(guān)聯(lián)詞 。 （ 關(guān)聯(lián)詞 與 MEDLINE副主題詞 相似） EMTREE 每年更新 Evidencebased Medicine 分為 : 快速檢索 高級(jí)檢索 字段檢索 藥物檢索 疾病檢索 文章檢索 主頁(yè)為快速檢索 , 可使用自然語(yǔ)言檢索，可用單詞或詞組進(jìn)行檢索，檢索詞組時(shí)需加單（雙）引號(hào)或連字符。如 : ‘clinical trial’或 clinicaltrial 。 可使用無(wú)限截詞符（ *）或有限截詞符（？），但 截詞符的使用不適用詞組。 Evidencebased Medicine Quick Search Evidencebased Medicine 高級(jí)檢索 ， Evidencebased Medicine More Limits ， Evidencebased Medicine 限定檢索 Evidencebased Medicine Drug Search Evidencebased Medicine Disease Search Evidencebased Medicine Article Search Evidencebased Medicine 檢索結(jié)果 Evidencebased Medicine 在檢索結(jié)果的界面下端，可運(yùn)用 Elsevier的科學(xué)搜索引擎 Scirus來(lái)對(duì)互聯(lián)網(wǎng)進(jìn)行搜索 。 Evidencebased Medicine 三、如何檢索除書(shū)目數(shù)據(jù)庫(kù)以外的文獻(xiàn) 補(bǔ)充檢索與主題有關(guān)的數(shù)據(jù)庫(kù) (supplementary subject databases） 檢索收錄各種指南的網(wǎng)站 (guidelines sites) 檢索會(huì)議摘要和學(xué)術(shù)會(huì)議錄網(wǎng)站 (meeting abstracts and conference proceedings) 檢索灰色文獻(xiàn)索引 (grey literature indexes) 檢索官方網(wǎng)站 (government/official websites) 檢索衛(wèi)生技術(shù)評(píng)估方面的網(wǎng)站 (other HTA websites) 檢索主要的在線(xiàn)書(shū)目數(shù)據(jù)庫(kù) (major online book catalogues) 檢索已注冊(cè)和在研的臨床試驗(yàn)數(shù)據(jù)庫(kù) 手工檢索相關(guān)雜志 Evidencebased Medicine 如何檢索除書(shū)目數(shù)據(jù)庫(kù)以外的研究文獻(xiàn) 還可參考 Cochrane Collaborationr的“ The Cochrane Handbook for Systematic Reviews of Interventions” (Version , updated September 2022)的相關(guān)內(nèi)容 ( Sources to search)進(jìn)行擴(kuò)展檢索 （見(jiàn)以下幾張幻燈片的內(nèi)容） Evidencebased Medicine 1. Journals and other nonbibliographicdatabase sources Handsearching Fulltext journals available electronically Tables of contents Conference abstracts or proceedings Other reviews, guidelines and reference lists as sources of studies Web Searching Evidencebased Medicine (1) Fulltext journals available electronically BioMed Central: PubMedCentral (PMC): Web sites listing journals offering free fulltext access include: Free Medical Journals: HighWire Press: Evidencebased Medicine (2) Tables of contents Many journals, even those that are available by subscription only, offer Table of Contents (TOC) services free of charge, normally through alerts or RSS feeds. In addition a number of anizations offer TOC services Evidencebased Medicine Examples of anizations offering Table of Contents (TOC) services British Library Direct (free): British Library Inside (to be replaced by British Library Direct Plus) (subscription): Current Contents (subscription): Scientific Electronic Library Online (SciELO) – Brazil (free): Evidencebased Medicine (3) specialist conference abstract sources Biological Abstracts/RRM (Reports, Reviews, Meetings): British Library Inside (to be replaced by British Library Direct Plus): British Library Direct Plus: /productsservices/bldplus ISI Proceedings: 從本校圖書(shū)館可查 Evidencebased Medicine (4) Other reviews, guidelines and reference lists as sources of studies Australian National Health and Medical Research Council: Clinical Practice Guidelines: Canadian Medical Association – Infobase: Clinical Practice Guidelines: National Guideline Clearinghouse (US): National Library of Guidelines (UK): New Zealand Guidelines Group: NICE Clinical Guidelines (UK): alguidelines/ Evidencebased Medicine 2. Unpublished and ongoing studies National and international trials registers Subjectspecific trials registers Pharmaceutical industry trials registers Trials results registers and other sources Evidencebased Medicine Examples of trials results registers International Federation of Pharmaceutical Manufacturers and Associations (IFPMA) Clinical Trials Portal: PhRMA Clinical Study Results Database: Research Findings Electronic Register (ReFeR) (no longer updated): BristolMyers Squibb Clinical Trial Results: Eli Lilly and Company Clinical Trial Registry: Roche Clinical Trials Results Database: Wyeth Clinical Trial Results: Evidencebased Medicine 有了機(jī)檢，為何還要手檢？ 手工檢索雜志作為計(jì)算機(jī)檢索的補(bǔ)充至少有以下兩個(gè)原因： 1. 書(shū)目文獻(xiàn)數(shù)據(jù)庫(kù)并非對(duì)全部的臨床試驗(yàn)文獻(xiàn)進(jìn)行了收錄； 2. 雖然臨床試驗(yàn)記錄被數(shù)據(jù)庫(kù)收錄，也可能由于在數(shù)據(jù)庫(kù)中使用的術(shù)語(yǔ)不易被識(shí)別出是臨床試驗(yàn)而不能被檢索出來(lái)。 Evidencebased Medicine 為何需手工檢索 RCT？ CENTRAL和 Cochrane協(xié)作網(wǎng)的檢索策略能檢出大多數(shù)已出版的英語(yǔ)雜志和相關(guān)數(shù)據(jù)庫(kù)收錄雜志中的完整的研究文獻(xiàn)，一些臨床試驗(yàn)未被檢索出來(lái)是由于這些記錄