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eijing (%) was higher than that in Shanghai (%), and there was also a higher prevalence of GER in male, in laboring people and in people of rural areas in Beijing as pared with Shanghai. (3) Logistic analysis indicated that GER had a close relatioship with dental, pharnyngolaryngeal disorders and respiratory diseases, such as asthma and bronchitis, etc. Conclusions GERD is different in the northern and southern area of China. Ratio between GERD and RE is 3∶1 in our study. Age40 (OR ), greasy food (OR ), big appetite (OR ), tiredness (OR ), emotional stress (OR ), pregnancy (OR ) and constipation (OR ) are the risk factors of GERD. 【Key words】 Gastroesophageal reflux Gastroesophageal reflux disease Reflux esophagitis 胃食管反流病(gastroesophageal reflux disease,GERD)是指過多的胃、十二指腸內(nèi)容物反流入食管,引起燒心、反酸、反食等,甚至有食管粘膜的病理性損害——反流性食管炎(reflux esophagitis,RE)。本癥還可引起口咽、喉、氣道等食管外的組織損害。北京協(xié)和醫(yī)院1986年對(duì)3 000例接受胃鏡檢查病人的調(diào)查表明,%[2];臺(tái)灣一所醫(yī)院對(duì)2 044例病人作胃鏡檢查,RE為5%[3]。本研究的目的:(1) 了解北京、上海兩市成人癥狀性GER的發(fā)生情況及GERD和RE的患病率,(2) 研究GER和呼吸道、口咽部疾患的關(guān)系,(3) 了解與GERD發(fā)病有關(guān)的危險(xiǎn)因素等。采用整群、分層和單純隨機(jī)抽樣的方法,對(duì)北京及上海市(簡稱兩市)18~70歲的常住城鄉(xiāng)居民各2 500例進(jìn)行問卷調(diào)查。對(duì)抽到的居委會(huì)符合年齡條件的居民,每戶每人,由經(jīng)過培訓(xùn)的調(diào)查員(多數(shù)為醫(yī)師,少數(shù)為醫(yī)學(xué)生和護(hù)士)在居(村)委會(huì)人員的陪同下,分別入戶進(jìn)行問卷調(diào)查?! 颖靖采w人群:北京市常住人口為1 100萬、上海市為1 300萬,18~70歲的人占兩市常住人口的73%;樣本量5 000例,覆蓋兩市各年齡組人群為:5000247。調(diào)查結(jié)束后,選擇部分被調(diào)查者的問卷由另人復(fù)核,%。以燒心、反酸、反食作為評(píng)分癥狀:無癥狀為0分,癥狀輕為1分,癥狀中等為2分,癥狀重為3分。根據(jù)癥狀程度及頻度,積分之和為總分(Sc),最高18分?! ∫陨蟂c≥6共448例,%,其中Sc≥10共138例,%;Sc<%。以這段時(shí)間內(nèi)有反流癥狀人群的檢出率代表患病率?! ∷匈Y料均經(jīng)中國協(xié)和醫(yī)科大學(xué)統(tǒng)計(jì)教研室復(fù)核,用卡方或Logistic回歸作統(tǒng)計(jì)學(xué)分析。精查項(xiàng)目包括體格檢查,常規(guī)化驗(yàn),血生化,心電,胸透,B超肝、膽、胰、脾;并均作胃鏡和24小時(shí)pH監(jiān)測(cè)。24小時(shí)pH監(jiān)測(cè)采用Diggitrapper MK Ⅲ pH監(jiān)測(cè)儀(瑞典CTDSynectics公司)。若24小時(shí)pH監(jiān)測(cè)有異常胃食管反流指標(biāo)和/或胃鏡下有食管炎(RE),可診斷為GERD。 結(jié)果 一、有GER癥狀者的患病率 (一) 不同年齡的患病率: 表2顯示,30~39歲年齡組Sc≥6的反流癥狀患病率已明顯增高,并在≥40各組仍然增高。 **:vs39歲,P< (二) 不同性別的患病率:被調(diào)查者男性2 346例,女性2 646例?! ?三) 不同職業(yè)的患病率:腦力勞動(dòng)(干部、知識(shí)分子、學(xué)生)和體力勞動(dòng)者GER的患病率未顯示明顯差別?! ?四) GERD和RE患病率的預(yù)測(cè)