freepeople性欧美熟妇, 色戒完整版无删减158分钟hd, 无码精品国产vα在线观看DVD, 丰满少妇伦精品无码专区在线观看,艾栗栗与纹身男宾馆3p50分钟,国产AV片在线观看,黑人与美女高潮,18岁女RAPPERDISSSUBS,国产手机在机看影片

正文內容

xxxx1102周三下午合成生物學nxp-在線瀏覽

2025-02-06 04:39本頁面
  

【正文】 ious scalability issues – Scavenging natural repressor proteins is time consuming – Matching natural repressor proteins to work together is difficult Cellular Logic Summary ? Sophisticated synthetic biological systems require a scalable cellular logic technology with good cooperativity – Zincfinger proteins can be engineered to create many unique proteins relatively easily – Zincfinger proteins can be fused with dimerization domains to increase cooperativity – A cellular logic technology of only zincfinger proteins should hopefully be easier to characterize Single ZincFinger Structure DNA Three Base Recognition Region Zinc Atom Alpha Helix Two Beta Sheets PolyFinger ZFPs . Jamieson, . Miller, and . Pabo. Drug discovery with engineered zincfinger proteins. Nature Reviews Drug Discovery, May 2023 Complex systems Q: But if we don’t fully understand all the rules of biology, how can we create anything more than basic systems? A: We can press our limits by modularizing and simplifying as much as possible. ? Standardization of Components – Predictable performance – Offtheshelf – Mechanical Engineering (1800s) the manufacturing revolution (. Henry Ford) ? Abstraction – Insulate relevant characteristics from overwhelming detail – Simple ponents that can be used in bination – From Physics to Electrical Engineering (1900s) ? Decoupling Design Fabrication – Rules insulating design process from details of fabrication – Enable parts, device, and system designers to work together – VLSI electronics (1970s) Enabling Synthetic Biology Characterization Placte tRO pLac Repr es so rTet Repr es so r? Catalog inputoutput characteristics of existing and new parts/devices Standardization ? Physical connections ? Functional connections ? Performance A PoPSIN PoPSOUT SB works via three layers of abstraction Devices Parts Systems Abstraction in biology Devices Parts Systems P lac te tRO pLac Repr es so rTet Repr es so rOO OOOMetab olic reacti onsDNABarriers Technological Legal Ethical Synthetic Biology: Intellectual Property ? Relationship of synthetic biology to intellectual property law has been largely unexplored. ? The relevant research space already contains broad patents on foundational technology. ? Synthetic biology mons? Tools of open source – property rights coupled with viral licensing Synthetic Biology: Intellectual Property ? What is patentable and/or copyrightable? – Broad biological functions – Specific sequences – Specific uses – Sources of uncertainty in synthetic biology as related to IPR definitions – What are effects of alternate definitions of what is patentable and copyrightable on: ? Development of field? ? Efficiency? ? Justice? Synthetic Biology: Intellectual Property ? Patents on fundamental ideas in synthetic biology Example: A patent on the idea of a biological part: a piece of DNA with specific function that can be bined with another part in a predefined fashion. ? Such a patent would be impossible to circumvent. It represents a fundamental concept that underpins synthetic biology. – See Stanford patent on System and method for simulating operation of biochemical systems. United States Patent 5914891 Synthetic Biology: Intellectual Property ? Patents on fundamental biological functions Example: A patent on a geicallyencoded inverter ? Such a patent would be almost impossible to circumvent because it represents a basic biological function that is of use in a range of synthetic biological systems. – See US Dept of Health patent on Molecular puting elements, gates and flipflops. United States Patent 6774222 – See Boston University patent on Multistate geic oscillator. United States Patent 6737269 – See Boston University patent on Bistable geic toggle switch. United States Patent 6841376 – See Boston University parent on Adjustable threshold switch. United States Patent 6828140 Synthetic Biology: Intellectual Property ? Patents on classes of biological molecules with a particular function Example: A patent on the use of zinc finger proteins to bind a specific sequence of DNA. ? Such a patent is not impossible to circumvent because there are other proteins that bind DNA and that could be engineered to bind new sequences. – See MIT patent on Poly zinc finger proteins with improved linkers. United States Patent 6903185 – See Scripps Research Institute patent on Zinc finger binding domains for GNN. United States Patent 6610512 – See Sangamo Biosciences, Inc. patent on Regulation of endogenous gene expression in cells using zinc finger proteins. United States Patent 6607882 Synthetic Biology: Intellectual Property ? Patent on a particular biological molecule. Example: A patent on the sequence of a particular protein that senses light and transmits a signal into the cell. ? Such a patent would likely be fairly easy to circumvent because there are probably a few amino acids that could be changed in the protein such that it would it would still be functional yet not have the exact same sequence as specified in the patent. ? There are exceptions to this rule: Some proteins that have been so optimized for a specific function that any mutation in the sequence can lead to less functionality (., the peptide drug Ziconitide). Open mons of biological functions Openaccess biology? ? When a technology is proprietary, both the ability and interest in examining troubleshooting problems is restricted to those with the IP ? Might openaccess biology generate a higher quality product? Or would it stifle innovation through a lack of interest? Programmed Organisms (編程性物種 ) ?
點擊復制文檔內容
教學課件相關推薦
文庫吧 www.dybbs8.com
備案圖鄂ICP備17016276號-1