藥理第9章--膽阻-展示頁(yè)
2024-11-04 04:41本頁(yè)面
【正文】 land (dryness of the skin) bronchial secretory gland (discharge decreased) stomach gland (Large dosage may inhibit the secretory function of the stomach),第五頁(yè)，共四十二頁(yè)。,2.抑制腺體分泌 唾液腺(口干), 汗腺(皮膚枯燥(gānz224。)。,第三頁(yè)，共四十二頁(yè)。li224。n)藥的分類,M cholinoceptor blocking drugs N1 Cholinoceptor Blocking Drugs (ganglionic blocking drugs〕 N2 Cholinoceptor Blocking Drugs (Skeletal muscle relaxants),第二頁(yè)，共四十二頁(yè)。 Mechanism of action: Anticholinergic drugs can combine with cholinergic receptors and inhibit ACh or cholinergic drugs to combine with M or N receptors.,第一頁(yè)，共四十二頁(yè)。Cholinoceptor Blocking Drugs Cholinergic antagonists,作用機(jī)制(jīzh236。)：抗膽堿藥與膽堿受體結(jié)合，阻斷Ach或擬膽堿藥對(duì)M和N受體的沖動(dòng)作用。,膽堿受體阻斷(zǔ du224。,第一節(jié) MCholinoceptor Blocking Drugs,阿托品(Atropine) A belladonna alkaloid, has a high affinity for M receptors, where it binds competitively, preventing acetylcholine from binding to that site. 競(jìng)爭(zhēng)性拮抗Ach對(duì)M受體的沖動(dòng)作用，大劑量(j236。ng)阻斷N受體。,Pharmacological effects,解除平滑肌痙攣：松馳多種內(nèi)臟平滑肌 特點(diǎn): (1)對(duì)過(guò)度活動(dòng)或痙攣的平滑肌松馳作用較顯著(xiǎnzh249。 (2)胃腸膀胱膽囊,膽管,輸尿管,支氣管,子宮,第四頁(yè)，共四十二頁(yè)。o))呼吸道腺體胃腺。,3.Eye: it blocks all cholinergic activity on the eye, resulting in dilation of pupil, unresponsiveness to light and inability to focus for near vision. In patients with glaucoma, intraocular pressure may rise dangerously. (1) 散瞳(mydriasis)：? (2) 眼內(nèi)壓升高(shēnɡ ɡāo)：?,第六頁(yè)，共四十二頁(yè)。b236。,第七頁(yè)，共四十二頁(yè)。,4.Cardiovascular system: Atropine produces divergent effects on the cardiovascular system, depending o
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