抗生素類藥物的分析(2)-展示頁
2025-06-04 12:03本頁面
【正文】 Isolated streptomycin（氯霉素） from Streptomyces griseus (soil microbes)。 ? 1928/9 Alexander Fleming Inhibition of S. aureus colonies by mold Penicillium notatum。 (Nobel Prize) (606, Salvarsan) syphilis (T. pallidum)。第十一章 抗生素類藥物的分析 Analysis of Antibiotics Drug History of Antibiotics ? ~ 1495 Europeans Mercury syphilis（梅毒） ? Chinese Moldy soybean curd boils燙傷 ? American Indians Chewed bark of cinchona tree malarial fever（瘧疾） ? ~ 1630 Europeans Quinine (bark of cinchona) malaria ? 1877 Louis Pasteur Inhibition of some microbes by others ? 1908 Gelmo Synthesized sulfanilamide磺胺 (1st sulfonamide) ? 190810 Paul Ehrlich Selective stains。 Synthesized arsenic pound arsphenamine。 Coined terms magic bullet, chemotherapy, chemical knife)。 (Nobel Prize) Discovered miracle drug penicillin ?1939 G. Domagk Therapeutic value of sulfonamides ( 磺胺 )。 (Nobel Prize) Proposed term antibiotic = chemical pound made by a microanism that inhibits or kills other microanisms at low concentrations ? ? 1945 Florey amp。 (Nobel Prize) Demonstrated practical clinical value as better means to prevent death from infection of war wounds ? A spore that drifted into his lab and took root on a culture dish started a chain of
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