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illation and no history of stroke or transient ischemic attack (TIA) ? Oral anticoagulant treatment ? Antiplatelet therapy ? Major vascular events (stroke. MI…) 10 Search strategy ? Cochrane Stroke Group Trials Register (June 2022 ? Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 2, 2022) ? MEDLINE (1966 to June 2022) ? EMBASE (1980 to June 2022). ? Atrial Fibrillation Collaboration and experts working in the field to identify unpublished and ongoing trials. 11 Selection criteria ? Randomized trials ? 8 randomized trials, including 9598 patients ? Longterm (more t