receptor-mediatedendocytosis受體介導的內(nèi)吞作用-展示頁
2024-10-24 15:06本頁面
【正文】 s an endocytotic mechanism in which specific molecules are ingested into the cell. The specificity results from a receptorligand interaction. Receptors on the plasma membrane of the target tissue will specifically bind to ligands on the outside of the cell. An endocytotic process occurs and the ligand is ingested. In 1964,Thomas Roth and Keith Porter reported on the mechanism by which yolk proteins might be taken into the oocytes（卵母細胞） of mosquitoes 報道了蚊子的卵黃蛋白進入卵母細胞的可能機制 一項實驗研究： 提出問題 → 觀察 → 推測 Raise the question: How are the highmolecularweight yolk proteins able to enter the oocyte? 問題的提出： 高相對分子質(zhì)量的卵黃蛋白如何進入卵黃細胞？ Notice: during stages of rapid oocyte growth, there was a dramatic increase in the number of pitlike depressions seen on the surface of the oocyte. 注意到： 在卵黃細胞快速 生長的階段，其細胞表面 小窩樣凹陷的數(shù)目劇增， 這些小窩是由質(zhì)膜的內(nèi)陷 形成的，并且在小窩的內(nèi) 表面覆蓋著一層剛毛狀的 外被。 Visualization of coated pits (P) and vesicles (V) suggested that endocytosis was specific. ROTH Postulation: yolk proteins were specifically adsorbed onto the outer surface of the membrane of the coated pits , which would then invaginate as coated vesicles. 推測： 卵黃蛋白特異地吸附在有被小窩膜的外表面，然后內(nèi)陷為 包被小泡 。 The first insight into the structure of coated vesciles Electron microscopic examination: a crude vesicle fraction isolated from guinea pig brains（ Figure1）
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