receptor-mediatedendocytosis受體介導(dǎo)的內(nèi)吞作用-文庫吧
2025-09-08 15:06 本頁面
【正文】 這是成熟的卵黃細(xì)胞的特征。 The first insight into the structure of coated vesciles Electron microscopic examination: a crude vesicle fraction isolated from guinea pig brains（ Figure1） 從豚鼠腦髓分離出粗制的小泡組分進(jìn)行電鏡觀察 Show: coated vesicles were covered by a polygonal basketwork. 表明： 包被小泡表面覆蓋著多邊形的編織物 Suggestion: the coatings were an apparatus to control the infolding of the plasma membrane during vesicle formation. 研究者提出： 外被是在小泡形成過程中用來控制質(zhì)膜折疊的裝置 The first studies of the biochemical nature of the vesicle coat 方法： 將來自豬腦的小泡經(jīng)過連續(xù)的蔗糖密度梯度離心，直到獲得純化的包被小泡。包被小泡的蛋白質(zhì)被溶解后經(jīng)過 SDS聚丙烯酰胺凝膠電泳分離。 結(jié)果表明： 外被含一種相對分子質(zhì)量約為 180000的優(yōu)勢蛋白質(zhì)。 Pearse將其命名為 網(wǎng)格蛋白 普遍性 :他再從其他幾種動物的不同類型的細(xì)胞中分離的包被小泡的樣品中，基于相對分子質(zhì)量和肽譜分析也發(fā)現(xiàn)了同樣的蛋白質(zhì) Brown and Goldstein had bee Interested in the inherited condition familial hypercholesterolemia (FH) People who were homozygous (純合子 )for the defective gene had profoundly elevated levels of serum cholesterol (800mg/dl person), invariably developed severely blocked arteries (atherosclerotic動脈粥樣硬化 ) and usually died from heart attack before the age of 20. At the time, very little was known about the fundamental physiologic or biochemical defects in this disorder. familial hypercholesterolemia (FH) 對缺陷基因 (FH等位基因 )為純合子的人，血清膽固醇的水平明顯升高達(dá) 800mg/dL（正常水平為 200mg/dL），全部產(chǎn)生嚴(yán)重的動脈阻塞 （動脈粥狀硬化）， 通常在20歲前死于心臟病發(fā)作。那時對這種病癥的基
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