細胞凋亡與衰老-文庫吧資料
2024-10-08 22:13本頁面
【正文】 ell division is cotrolled not only by extracellular mitogens but also by intracellular mechanisms that can limit cell proliferation. Cellcycle arrest or apoptosis induced by excessive stimulation of mitogenic pathways. Extracellular growth factors stimulate cell growth Activation of cellsurface receptors Activation of PI 3kinase Activation of elF4E (translation initiation factor) and S6 kinase(phosphorylates ribosomal protein S6) Increasing protein synthesis and cell growth , Programmed cell death Biological functions of apoptosis ? In development, homeostasis, tumor surveillance, and the function of the immune system. ?細胞凋亡是多細胞生物在發(fā)育過程中，一種由基因控制的主動的細胞生理性自殺行為。 Morphological and biochemical characteristics of apoptosis ? Morphologi changes: Early : Chromosome condensation, cell body shrink Later : Blebbing and Nucleus and cytoplasm fragment— Apoptotic bodies At last: Phagocytosed A、 Normal cell B、 Apoptosis: Apoptotic bodies ? Biochemical characteristics of apoptosis : Apoptosis induced by Cyto C Lane 1． 0 h 2． 1 h 3． 2 h 4． 3 h 5． 4 h 6． C
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