【正文】
pharmacokinetic model is the single partment openmodel system. This model depicts the body as one partment characterized by a certain volume of distribution (Vd) that remains constant.l In the twopartment system, a drug enters into and is instantaneously distributed throughout the central partment.Its subsequent distribution into the second or peripheral partment is slower.8 Powders are intimate mixtures of dry, finely divided drugs and /or chemicals that may be intended for internal or external use. . tablets, capsules, liquid dosage forms, ointments and creams.粘附性(adhesion)是指不同分子間產(chǎn)生的引力,如粉體粒子與器壁間的粘附。每種藥品符合同樣的或各自的外觀和其他相應(yīng)的性質(zhì)如規(guī)格、質(zhì)量、純度,包括效價(jià),含量均勻性、崩解時(shí)間和溶出速率。但并不一定包含相同的非活性成分,具有相同的外觀或其他相應(yīng)的性質(zhì)如規(guī)格、質(zhì)量、純度,包括效價(jià)、含量均勻性、崩解時(shí)間和溶出速率。)藥物動(dòng)力學(xué)The area of study which elucidates the time course of drug concentration in the blood and tissues is termed pharmacokinetics.It is the study of the kinetics of absorption, distribution, metabolism and excretion (ADME) of drugs and their corresponding pharmacologic, therapeutic, or toxic response in animals and man.Pharmacokinetics also may be applied in the study of interactions between drugs.Active transport denotes a process of the solute or drug being moved across the membrane against a concentration gradient, that is, from a solution of lower concentration to one of a higher concentration or, if the solute is an ion, against an electrochemical potential gradient(主動(dòng)轉(zhuǎn)運(yùn)是指溶質(zhì)或藥物穿過(guò)生物膜的轉(zhuǎn)運(yùn)的過(guò)程是逆濃度梯度進(jìn)行,即從低濃度向高濃度轉(zhuǎn)運(yùn)或當(dāng)溶質(zhì)是離子時(shí)逆電化學(xué)電勢(shì)梯度轉(zhuǎn)運(yùn)。它應(yīng)該易于生產(chǎn),費(fèi)用低,制劑產(chǎn)品美觀,在不同的使用和貯藏條件下物理和化學(xué)上穩(wěn)定。)a lead poundis a prototype(原形化學(xué)物質(zhì)) chemical pound that has a fundamental desired biologic or pharmacologic activity.(先導(dǎo)化合物是一種具有生物學(xué)和藥理學(xué)活性基本要求的原型化學(xué)物質(zhì)。ISO 9000ISO9004 used in the pharmaceutical industryl ISO included standards pertaining to development, production, quality assurance, quality control, detection of defective products, quality management, and other issues as product safety and liability.l ISO 包括標(biāo)準(zhǔn)適合開(kāi)發(fā)、生產(chǎn)、質(zhì)量保證、質(zhì)量控制、缺陷產(chǎn)品的檢測(cè)、質(zhì)量管理和其他如產(chǎn)品安全性和責(zé)任的問(wèn)題。 poiein, meaning “make”。1. What is pharmaceutics? How many branches of pharmaceutics ? 2. What is a drug? Give some examples A drug is defined as an agent intended for use in the diagnosis, mitigation, treatment, cure, or prevention of disease in humans or in other animals. 藥物是有目的地用于診斷、緩解、治療、治愈或預(yù)防人類或動(dòng)物疾病的物質(zhì)。l Emetic (induce vomiting催吐劑) and antiemetic (prevent vomiting止吐劑) drugsl Diuretic drugs (increase the flow of urine利尿劑)l Expectorant drugs (increase respiratory tract fluid除痰劑)l Cathartics or laxatives (evacuate the bowel瀉藥) l Other drugs decrease the flow of urine, diminish body secretions, or induce constipation (便秘)Drug standardsl The united states pharmacopeia (藥典) and the national formulary (國(guó)家藥品標(biāo)準(zhǔn))l Pharmakon, meaning “drug”。l The bination indicates any recipe or formula or other standards required to make or prepare a drug. l Organized sets of monographs or books of these standards are called pharmacopeias or formularies.International Organization for standardization (ISO)is an international consortium of representative bodies constituted to develop and promote uniform or harmonized international standards.國(guó)際標(biāo)準(zhǔn)化組織是一個(gè)代表性的國(guó)際聯(lián)合會(huì),其設(shè)立是為了發(fā)展和