immuneresponse免疫應(yīng)答(參考版)
2024-10-06 16:35本頁(yè)面
【正文】 IL5 B cell proliferates into Plasma and Memory cells 。 IL4 activate T cell, causing proliferation amp。 cellmediated immune systems Multiple sclerosis ?? demyelinization of CNS tissue, progressive paralysis lesions resemble cellular infiltrates associated with delayed hypersensitivity reactions Juvenile or Type I diabetes T cells attack the ?cells of the pancreas Etiology of Autoimmune disseases Tolerance T suppressors hold system in check ‘clonal deletion’ eliminates cells able to respond to ‘self’ Autoimmunity clones not deleted hidden antigen now exposed antigens not made early now produced viral induced changes crossreactive antigens bacterial or viral infection triggers antibody production to cell ponents AIDS Human immunodeficiency virus Virus capsid ponent gp120 TH lymphocyte surface receptor CD4 Depletion of TH cells ELISA test for infection Vaccination?? Role of other cells Macrophages ‘Antigen Presenting Cell’ (APC) engulf antigen。 T cells amp。 cellmediated immune systems Multiple sclerosis ?? demyelinization of CNS tissue, progressive paralysis lesions resemble cellular infiltrates associated with delayed hypersensitivity reactions Hashimoto’s thyroiditis antibodies against thyroid epithelial cells amp。 T cells amp。 cellmediated immune systems Hashimoto’s thyroiditis antibodies against thyroid epithelial cells amp。 T cells amp。 pain proteolytic enzymes of neutrophils degrade collagen repeated bouts lead to fibrous tissue replacing collagen joint fusion Hashimoto’s thyroiditis antibodies against thyroid epithelial cells amp。 T cells deleted Autoimmunity breakdown of Tolerance, system failure a) antigen exposed b) antigen produced (viral infection, cancer) c) B amp。 phagocytes attack, releasing lytic enzymes hours Type IV: delayed hypersensitivity/cell mediated reactions mediated by T cells which release lymphokines macrophage accumulation and activation begins 1824 hr, peak at 2448 hr rash of small pox, measles。 phagocytes attack, releasing lytic enzymes hours Hypersensitivity Reactions Type I: anaphylaxis mediated by IgE rapid response: blood vessel dilation, hypotension, shock insect venom Type II: cytolytic/cytotoxic reactions mediated by IgG, IgM bind to cell, initiate plement cascade amp。 lysis Hypersensitivity Reactions Type I: anaphylaxis mediated by IgE rapid response: blood vessel dilation, hypotension, shock insect venom Type II: cytolytic/cytotoxic reactions mediated by IgG, IgM bind to cell, initiate plement cascade amp。 activation of monocytes and macrophages Cytotoxic effects: T cytotoxic (TC) or killer T
環(huán)評(píng)公示相關(guān)推薦
鄂ICP備17016276號(hào)-1