immuneresponse免疫應答-資料下載頁
2025-09-25 16:35本頁面
【正文】 to antibody AgAb plexes filtered by kidney, against basement membrane of glomerulus activate plement cascade tissue damage Rheumatoid arthritis abnormal IgM rheumatoid factor reacts with the Fc portion of IgG AgAb plexes deposited in synovia activate plement cascade inflammatory response with increased vascular permeability swelling amp。 pain proteolytic enzymes of neutrophils degrade collagen repeated bouts lead to fibrous tissue replacing collagen joint fusion Hashimoto’s thyroiditis antibodies against thyroid epithelial cells amp。 thyroglobulin in serum thyroid follicles infiltrated with B cells amp。 T cells amp。 macrophages follicles destroyed damage by humoral amp。 cellmediated immune systems Hashimoto’s thyroiditis antibodies against thyroid epithelial cells amp。 thyroglobulin in serum thyroid follicles infiltrated with B cells amp。 T cells amp。 macrophages follicles destroyed damage by humoral amp。 cellmediated immune systems Multiple sclerosis ?? demyelinization of CNS tissue, progressive paralysis lesions resemble cellular infiltrates associated with delayed hypersensitivity reactions Hashimoto’s thyroiditis antibodies against thyroid epithelial cells amp。 thyroglobulin in serum thyroid follicles infiltrated with B cells amp。 T cells amp。 macrophages follicles destroyed damage by humoral amp。 cellmediated immune systems Multiple sclerosis ?? demyelinization of CNS tissue, progressive paralysis lesions resemble cellular infiltrates associated with delayed hypersensitivity reactions Juvenile or Type I diabetes T cells attack the ?cells of the pancreas Etiology of Autoimmune disseases Tolerance T suppressors hold system in check ‘clonal deletion’ eliminates cells able to respond to ‘self’ Autoimmunity clones not deleted hidden antigen now exposed antigens not made early now produced viral induced changes crossreactive antigens bacterial or viral infection triggers antibody production to cell ponents AIDS Human immunodeficiency virus Virus capsid ponent gp120 TH lymphocyte surface receptor CD4 Depletion of TH cells ELISA test for infection Vaccination?? Role of other cells Macrophages ‘Antigen Presenting Cell’ (APC) engulf antigen。 cut to epitopes epitopes bond to MHC class II on surface T cell with appropriate receptor recognizes MHC + epitope (CD4 receptor on T cell) APC secretes Interleukin 1 (IL1), activating T cell T cell secretes other IL molecules Il2 amp。 IL4 activate T cell, causing proliferation amp。 release or IL4 amp。 IL5 B cell proliferates into Plasma and Memory cells
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