【正文】
Toxic Megacolon ? usually fulminant and severe type: involves muscular layer and myenteric plexus, with hypotonia of intestinal wall and acute colonic expanding. ? Abdominal pain, distension, rebound pain, loss of bowel sound. Xray TestExpansion of the gut cavity and haustrum. ? prone to perforation, mortality 20~30%. ? incentivs: Barium enema, hypokalemia,anticholinergic drugs opiates... ?BE CAREFUL with spasmolysis agents and antidiarrheal agents to avoid inducing toxic megacolon 癌變的監(jiān)測(cè) ? 病程 8- 10年以上的廣泛性結(jié)腸炎、全結(jié)腸炎 ? 病程 30- 40年以上的左半結(jié)腸炎、直乙狀結(jié)腸炎 ? UC合并原發(fā)性硬化性膽管炎 ? 監(jiān)測(cè)性結(jié)腸鏡檢查,至少 2年 1次,作多部位活檢 ? 有異型增生者,更應(yīng)密切隨訪,如為重度異型增生,一經(jīng)確認(rèn)即行手術(shù)治療 2022/4 6 months later tubular adenoma, mild dysplasia 77 y Male ( rectum) Moderately differentiated adenocarcinoma, partially with invasive micropapillary carcinoma ( 10%) cm 6 years later 2022/7 Colon Cancer( T3N1) Borrmann III With rectal fistula 緩解期的治療 緩解期 UC的治療 ? 除初發(fā)病例、輕癥遠(yuǎn)段結(jié)腸炎患者癥狀完全緩解后可停藥觀察外,所有患者完全緩解后均應(yīng)繼續(xù)維持治療 ? SASP的維持治療劑量一般為控制發(fā)作之半,多用2- 3 g/d,并同時(shí)口服葉酸。