【正文】 Yalkowsky, SH，Enhanced intestinal absorption of cyclosporine in rats through the reduction of emulsion droplet size，Pharm. Res. 1989,6(1): 4043.[13] Charman ., Charman ., Rogge ., et al, Selfemulsifying drug delivery systems: formulation and biopharmaceutic evalution of an investigational lipophilic pound, Pharm Res, 1992,9(1): 8793[14] Constantinides ., Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects, Pharm Res, 1995,12(11): 15611572[15] . Hauss, . Fogal, . Ficorilli, . Price, et al, Lipidbased delivery systems for improving the bioavailability and lymphatic transport of a poorly watersoluble LTB4 inhibitor, J. Pharm. Sci. 1998, 87: 164169.[16] J. Grevel, E. Nuesch, E. Abisch, K. Kutz, Pharmacokinetics of oral cyclosporin A (Sandimmun) in healthy subjects, Eur. J. Clin. Pharmacol. 1986,31:211216.[17] . Shah, . Carvajal, . Patel, ., et al, Selfemulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs, Int. J. Pharm. 1994,106:1523.[18] N. Farah, . Laforet, J. Denis, Selfmicroemulsifying drug delivery systems for improving dissolution of drugs: in vitro/in vivo evaluation, Pharm. Res. 1994,11: S202[19] . Constantinides, Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects, Pharm. Res. 1995,12:15611572.[20] J. Vonderscher, A. Meinzer, Rationale for the development of Sandimmune Neoral, Transplant. Proc. 1994,26:29252927.[21] . Rang, . Miller, Spontaneous emulsification of oils containing hydrocarbon, nonionic surfactant, and oleyl alcohol, J. Colloids Interface Sci. 1999,209:179192.[22] M. Kimura, M. Shizuki, K. Miyoshi, et al, Relationship between the molecular structures and emulsification properties of edible oils, Biosci. Biotech. Biochem., 1994, 58:12581261.[23] . Hauss, . Fogal, . Ficorilli, et al, Lipidbased delivery systems for improving the bioavailability and lymphatic transport of a poorly watersoluble LTB4 inhibitor, J. Pharm. Sci. 1998,87:164169.[24] T. Amemiya, S. Mizuno, H. Yuasa, J. Watanabe, Development of emulsion type new vehicle for soft gelatin capsule.： I. Selection of surfactants for development of new vehicle and its physicochemical properties, Chem. Pharm. Bull. 1998，46: 309313.[25] . Serajuddin, P. C. Sheen, D. Mufson, . Bernstein, . Augustine, Effect of vehicle amphiphilicity on the dissolution and bioavailability of a poorly watersoluble drug from solid dispersion, J. Pharm. Sci., 1988,77: 414417[26] 李國棟，范偉，居紅衛(wèi)等，自乳化釋藥系統(tǒng)的研究進(jìn)展，國外醫(yī)藥—合成藥 生化藥 制劑分冊，2001，22（5）：304305，314[27] Pouton C W, Formulation of selfemulsifying drug delivery system s. Advanced D rug Delivery Reviews, 1997, 25 (4) : 4758.[28] Craig D Q M , Lievens H S R, Pitt K G, et al. An investigation into the physicochemical properties of selfemulsifying systems using low frequency dielectric spectroscopy, surface tension measurements and particle size analysis. Int J P harm , 1993, 96(7) : 147155.[29] . Pouton, Selfemulsifying drug delivery systems: assessment of the efficiency of emulsification, Int. J. Pharm. 1985,27:335348.[30] . Pouton. Effects of the inclusion of a model drug on the performance of selfemulsifying formulation. J P harm P harm acol, 1985, 37 (1) : 111.[31] Florence AT. The oral absorption of micro and nano particulates: neither exceptional nor unusual. P harm Res, 1997, 14 (3) : 259266.34 / 34。參考文獻(xiàn)：[1]顧斌，吳德政，紫杉醇的藥理學(xué)研究進(jìn)展[J]，中國藥理學(xué)通報(bào)，1998，14（5）：393396[2]顧覺奮，杜昱，抗癌新藥紫杉醇的研究概述[J]，國外醫(yī)藥抗生素分冊，2000，21（2）：51－53[3]魯明波，梅興國，紫杉醇的臨床應(yīng)用進(jìn)展[J]，國外醫(yī)－合成藥、生化藥、制劑分冊，1997年第18卷第二期：94－100[4]施斌, 裴元英，紫杉醇及其制劑研究進(jìn)展[J]，中國臨床藥學(xué)雜志，2004，13（6）：389392[5] Gershanik, T., S. Benzeno, and S. Benita, Interaction of a selfemulsifying lipid drug delivery system with the everted rat intestinal mucosa as a function of droplet size and surface charge. Pharm Res, 1998. 15(6): p. 863839.[6] Krishna G, Sheth BB. A novel self emulsifying parenteral drug delivery system，J Pharm Sci Technol，1999,53(4):168176[7] N. H. Shah, M. T. Carvajal, C. I. Patel, M. H. Infeld and A. W. Malick, Selfemulsifying drug delivery systems