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The First Clinical College of Harbin Medical University 。 The First Clinical College of Harbin Medical University ?睡前給予 降壓藥物能夠有效降低夜間血壓, 恢復(fù)血壓杓型狀態(tài)。 ? 夜間高血壓對(duì)心、腦和腎臟等 靶器官損害更嚴(yán)重 。 p ) and lower urinary albumin excretion (31 vs 47 mg/24h。 12 mmHg。50(6):90817 The First Clinical College of Harbin Medical University ? After the shift, dipping increased in 94% of patients, with normal circadian rhythm restored in 88% . ? Nocturnal SBP was significantly decreased (114177。 ? 長(zhǎng)效制劑 有利于夜間高血壓控制, 有助于血壓晨峰控制。 ? Have a favorable effect on nocturnal hypertension. J. Hypertens. 24(10), 2047–2055 (2020). Minerva Endocrinol. 29(1), 11–17 (2020). The First Clinical College of Harbin Medical University ?不宜選擇具 中樞鎮(zhèn)靜作用降壓藥 以免加重呼吸暫停,如利血平、可樂定等。 Am. J. Med. 119(10), 898–902 (2020). Am. J. Hypertens. 18(12 Pt 1), 1614–1618 (2020) The First Clinical College of Harbin Medical University ?阿司匹林 ? A potent antioxidative agent that reduces vascular production of superoxide, prevents angiotensin II–induced hypertension, and induces NO release. The First Clinical College of Harbin Medical University ? 257 patients with mild hypertension (100 mg) . ? Significant blood pressure reduction was observed in patients who received aspirin at bedtime (P) . ? The reduction in nocturnal BP was double in nondippers () pared with dippers (。 27: 876–885 The First Clinical College of Harbin Medical University 其他藥物 ?褪黑素 ? 由松果體腺分泌,能夠改善內(nèi)皮功能,增加 NO合成, 導(dǎo)致血管擴(kuò)張和降壓效應(yīng)。 ? βblockers have not been well studied to date. . Hypertens. 14(5), 453–459 (2020). Pharmaco. Ther. 111(3), 629–651 (2020). The First Clinical College of Harbin Medical University ?利尿劑 利尿劑對(duì)血壓晝夜模式 無明顯影響 (鹽敏感高血壓除外) , 仍有待大規(guī)模臨床研究證實(shí)。 p = ) , also acpanied by greater sleepBP lowering (% vs 6% fall。 ? OSAHS 患者 RAAS亢進(jìn), RAAS拮抗劑 能夠明顯 降低 24 h 血壓,且具改善呼吸暫停及睡眠結(jié)構(gòu)作用。16(2):1015 The First Clinical College of Harbin Medical University ? 對(duì)嚴(yán)重自主神經(jīng)病變導(dǎo)致 仰臥位高血壓者 , 睡眠時(shí)頭部抬高 有助于降低仰臥位血壓 。 ? 睡眠障礙者 非杓型高血壓發(fā)生率增加 3倍 。 ? 補(bǔ)鉀最可通過多食用含鉀豐富的 水果 、 蔬菜 等或 添加鉀鹽 (低鈉鹽)。 Hypertension, 2020, 51: 22522231 The First Clinical College of Harbin Medical University ? 美國(guó)全國(guó)高血壓教育項(xiàng)目協(xié)調(diào)委員會(huì)( NHBPEP) 推薦的 鉀與鈉攝入比為 2: 1。 Blood press monit. 1996 Dec。 Circulation. 1997 Sep 16。 ? Uzu 等證實(shí):鹽敏感性高血壓患者限鹽程度 與夜間血壓下降幅度 呈正相關(guān) 。 ? 治療涉及 生活方式 干預(yù)、 藥物 時(shí)間治療學(xué) 和 相關(guān)疾病 的治療。 J Am Soc Nephrol. 2020. 5(2): 2815 The First Clinical College of Harbin Medical University Hypertension. 2020 Apr。 ? 夜間睡眠時(shí)間減少 98分鐘 ( P< ) , 睡眠效率由 82% 降至 77%( P=) 。50:333339 The First Clinical College of Harbin Medical University ? AHA夜間血壓診斷標(biāo)準(zhǔn): Hypertension. 2020 Jul。 The First Clinical College of Harbin Medical University ? 有研究顯示 , ABPM 監(jiān)測(cè)出的夜間高血壓患 74 例 在使用診室血壓監(jiān)測(cè)時(shí) 僅有 4 名 被檢測(cè)出患有高血壓。12:19–24 The First