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【正文】 nst grampositive bacteria paticularly staphylococci ? Pharmacokiics ? Poorly absorbed from intestinal tract, iv ? Excreted from glomerular filtration 90% Vanycin ? Clinical uses ? Infection caused by MRSA, MRSE and penicillinresistant pneumococcus ? Treatment of antibioticassociated enterocolitis caused by clostridium difficile po ? Adverse reaction ? Ototoxicity nephrotoxicity ? Redman syndrome Teicoplanin ? Similar to vanycin in mechanism and antimicrobial spectrum ? Can be given im as well as iv ? Less adverse reactions Polymyxins ? Active only against gramnegative rods, particularly ? Mechanism:increase permeability of cell membrane ? Mainly used in infection when other drugs are resistant ? Toxicity: nephrotoxicity neurotoxicity Baciteracin ? Active against grampositive bacteria ? Inhibit cell wall formation ? No crossresistance with other agents ? Topical use only because of nephrotoxicity 演講完畢,謝謝觀看!
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