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inducible factors: central regulators of the tumor phenotype[J]. Curr Opin Genet Dev,2007,17(1):7177.[12] Maxwell PH, Wiesener MS, Chang GW, et al. The tumor suppressor protein VHL targets hypoxiainducible factors for oxygendependent proteolysis[J]. Nature, 1999,399(6733): 271275.[13] Fang J, Yan L, Shing Y, et al. HIF1α mediated upregulation of vascular endothelial growth factor, independent of basic fibroblast growth factor, is important in switch to the angiogenic phenotype during early tumorigenesis[J]. Cancer Res,2001,61(15):57315735.[14] Kim JW, Tchernyshyov I, Semenza GL, et al. HIF1 mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia [J]. Cell Metab,2006,3(3):177185.[15] LopezRios F,SanchezArago M,GarciaGarcia E,et al. Loss of the mitochondrial bioenergetic capacity underlies the glucose avidity of carcinomas [J]. Cancer Res, 2007,67(19):90139017.[16] Yun J,Rago C,Cheong I,et deprivation contributes to the development of KRAS pathway mutations in tumor cells[J].Science,2009,325(5947):15551559[17] Halfter UM et al.[J]Biochem ,2004,388:1728.[18] Bensaad K, Tsuruta A, Selak MA, et al. TIGAR, a p53inducible regulator of glycolysis and apoptosis[J]. Cell,2006,126(1):107120.[19] Luo xiangjian, Cao ya. Progress in Biochemistry and Biophysics[J]. 2011,38(7):585592..