cholinoceptorblockingdrugs-資料下載頁(yè)
2025-07-15 18:09本頁(yè)面
【正文】 noceptor Blocking Drugs ? Skeletal muscle relaxants ? It bines with N2receptor of motor endplate on postsynaptic membrane, the transmission of nerve impulse is blocked, leading to skeletal muscle relaxation. ? divide into two classes on the basis of their mechanism of action ? Depolarizing muscular relaxants: succinylcholine ? Nondepolarizing muscular relaxants: dtubercurarine Depolarizing muscular relaxants ? Mechnism – Binds to Nm receptor – Depolarize longer than Ach – Depolarization nondepolarization Depolarizing muscular relaxants ? Quiver before relaxation ? Acute tolerance ? Cholinesterase inhibitors can strength its effects ? Can not block NNreceptors in ganglion Succinylcholine ? Clinical uses: – Guttural muscle are more sensitive to succinylcholine – Bronchoscope examination, esophagoscope examination Adverse responses ? Asphyxia ? Fascicle quiver ? blood plasma ? Idiosyncratic reaction Nondepolarizing muscular relaxants ? dtubercurarine
環(huán)評(píng)公示相關(guān)推薦
鄂ICP備17016276號(hào)-1