疫antigppt課件-資料下載頁
2025-05-01 18:21本頁面
【正文】 when mixed with an immunogen, enhances the immune response against the immunogen. The use of adjuvants, however, is often hampered by undesirable side effects such as fever and inflammation. CFA, IFA, BCG, CP, LPS, CpG Antigen Some Key Points ?An antigen is defined by any molecule which is recognized by an B cell surface antibody (B cell antigen receptor) or secreted antibody, or by a T cell antigen receptor. ?An antigenic determinant (=epitope) is a defined site of recognition of an antigen by either specific B cell or T cell receptors. ?An immunogen is an antigen that initiates an immune response upon recognition by antigen receptors (various properties influence immunogenicity). ?T cell receptors only recognize antigenic peptides when presented by MHC molecules expressed on the surface of antigen presenting cells. ?Superantigens stimulate a larger number of T cells than normal antigens by reacting both with the MHC presenting molecule and a large subset of T cell receptors. Test 1. Which of the following antigens is most likely to be a hapten?( ) A. Red blood cells B. Penicillin C. Serum albumin D. Staphylococcus Aureus E. Lipopolysaccharide 2. Which of the following is the first requirement for a pound to be immunogenic? ( ) A. Molecular size B. Chemical plexity C. Foreignness D. Physical form E. Dose administered 3. Which of the following is most likely regarding T cell epitopes? ( ) A. They are recognized in the context of an MHC molecule B. They require processing before the B cell can bind to them C. They are generally hydrophilic D. They are often made up of nucleotides E. They may include amino acids from several sites in the molecule that end up near each other in the final 3D conformation Introduction
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