化學(xué)制藥技術(shù)畢業(yè)論文-胰島素新劑型的研究與進(jìn)展-中英文資料外文翻譯(編輯修改稿)
2024-08-29 20:01 本頁面
【文章內(nèi)容簡介】 ntially damage the nasal mucosa and the risk of ciliary motility [14]. Oral administration The absorption surface area of buccal mucosa 100 cm2 ~ 200cm2, transparent sound, low protease activity, vascular rich. Therefore, the buccal mucosa administration of peptide drugs may well be a more suitable route of administration. Buccal delivery formulations Orallyn by the INS and the absorption of rebinant 共 12 頁 第 5 頁 human promoter position, with the Rapid MistTM device can be drugs to highspeed, small form mist sprayed into the mouth, 40min ~ 60 min after administration to reach peak concentration, 240 min to a minimum concentration [15]. rectal INS rectal suppository is an important way to replace the one injection. To increase absorption, which need to add absorption enhancer. Rectal administration method has two advantages: ① rectum close to neutral or slightly alkaline pH, and low hydrolase activity, drug rarely been destroyed。 ② can basically avoid the liver firstpass effect. Therefore, rectal administration is a rather ideal route of administration. Since INS is a macromolecular drugs, the rectum is relatively difficult to absorb, and thus promote the absorbent be added to improve the bioavailability [16]. Transdermal Drug Delivery Hydrolase activity in the skin is very low, transdermal administration may be beneficial to INS, but the large proteins generally difficult to perate the skin, iontophoresis technology to the electric field has been absorbed into the bloodstream through the skin, the stratum corneum. Cuticle of the macromolecular peptide transdermal drug absorption is poor, but as long as appropriate measures and systemic treatment can play a role through the skin. Ryszka [17] made the ointment INS, INS released from the ointment out of the matrix, through the skin into the circle, and a certain amount of in vivo release correlation. Ultrasonic peration technique can significantly improve the drug percutaneous absorption and improve the local concentration of drug, transdermal drug delivery is a promising alternative. However, there are many ultrasonic peration technology limitations, you need the skin to ultrasound system tolerance and percutaneous peration, and ultrasound technology and chemical peration enhancers, iontophoresis, electroporation technology synergies [18]. 3 Summary With the new technology INS drug delivery systems, the continuous development of new methods, health care workers will have more options, all hospitals should strengthen continuing education for the patient39。s condition and needs, choose the most suitable mode of administration, to meet the needs of individual treatment [19]. References: 共 12 頁 第 6 頁 [1] Shaikh IM, Jadhav KR, Ganga S, et approaches in insulin delivery [J].Curr Pharm Biotechnol, 20xx,6 (5) :387395. [2]Chen Yan. Diabetes insulin Treatment of [M]. Beijing: Golden Shield Press ,20xx:156159. [3] Zhong Yiping. insulin topical treatment of pressure ulcers [J]. Nurses Training Magazine, 20xx,17 (1): 486. [4]Cefalu WT. Evolving strategies for insulin delivery and therapy [J]. Drugs, 20xx,64 (11) :11491161. [5] Li Changchen Type 2 diabetes, evaluated the pros and cons of insulin therapy [J]. Practical Diabetology, 20xx,10 (2): 10. [6]Brain the opportunity of tight glycaemic control inhaled insulin:Safety[J].Diabetes Obes Metab,20xx,7(Sup
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