第二章實(shí)驗(yàn)動(dòng)物標(biāo)準(zhǔn)化(nxpowerlite)(編輯修改稿)
2025-04-02 20:33 本頁(yè)面
【文章內(nèi)容簡(jiǎn)介】 sequently, if you turned the lights on to work in a room containing animals on such an experiment and you failed to turn the lights off when you leave the room, you can greatly alter the oute of the study. ? Environmental FactorsTemperature and Humidity: Room temperature and humidity levels are selected to meet the needs of the species of animals housed there and the Heating Ventilation and Air Conditioning (HVAC) system is balanced throughout the building to maintain the established settings. If doors or windows are left open the system gets out of balance and the correct conditions cannot be maintained. ? noiseSeparation of human and animal areas minimizes disturbances to both the human and animal occupants of the facility. Noisy animals such as dogs, swine, and nonhuman primates are usually housed away from quieter animals such as rodents, rabbits, and cats. Noise can have very detrimental effects on certain animals as illustrated by the recognition that certain strains of mice will go into convulsions when exposed to sudden loud noises. ?溫度對(duì)藥物毒性反應(yīng) LD50的影響 ?微量元素對(duì)動(dòng)物健康的影響 ?環(huán)境潔凈程度對(duì)腫瘤接種成功率的影響 ?動(dòng)物社會(huì)關(guān)系的影響 ? 按微生物控制程度分類(lèi)，實(shí)驗(yàn)動(dòng)物的環(huán)境可分為 ? 開(kāi)放系統(tǒng) ? 屏障系統(tǒng) ? 隔離系統(tǒng) 屏障系統(tǒng) 隔離系統(tǒng) 屏障環(huán)境特點(diǎn)： ?恒溫（ 20～ 26）恒濕（ 40％～ 70％） ?足夠的換氣次數(shù)（ 10～ 20次 /小時(shí)）保證有害氣體濃度降低到最小 ?正向梯度壓差（ 20～ 50)使屏障外污染源不能進(jìn)入 ?萬(wàn)級(jí)空氣潔凈度保證空氣潔凈 ?適合的動(dòng)物照度 (15~20)和對(duì)時(shí)明暗交替（ 12h/12h)符合動(dòng)物生活習(xí)性。 隔離環(huán)境特點(diǎn)： 百級(jí)空氣潔凈度 正向梯度壓差（ 100～ 150) 換氣次數(shù)（ 20～ 50次 /小時(shí)） 人員不與動(dòng)物直接接觸 第二節(jié) 實(shí)驗(yàn)動(dòng)物標(biāo)準(zhǔn)化的研究?jī)?nèi)容 一、實(shí)驗(yàn)動(dòng)物微生物學(xué)的控制 二、實(shí)驗(yàn)動(dòng)物遺傳質(zhì)量的控制 三、實(shí)驗(yàn)動(dòng)物環(huán)境的控制 四、實(shí)驗(yàn)動(dòng)物營(yíng)養(yǎng)的控制 實(shí)驗(yàn)動(dòng)物按微生物寄生蟲(chóng)控制分級(jí)： ?普通動(dòng)物 ?清潔動(dòng)物 ?SPF動(dòng)物 ?無(wú)菌動(dòng)物 小鼠，大鼠 ：清潔級(jí)， SPF級(jí)，無(wú)菌級(jí) 豚鼠，兔，地鼠 ：普通級(jí)，清潔級(jí)， SPF級(jí)，無(wú)菌級(jí) 犬，猴 ：普通級(jí)， SPF級(jí) 實(shí)驗(yàn)動(dòng)物環(huán)境分級(jí)： ?開(kāi)放環(huán)境 ?屏障環(huán)境 ?隔離環(huán)境 開(kāi)
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