疫4月17hypersensitivity(編輯修改稿)
2024-09-07 14:34 本頁面
【文章內(nèi)容簡介】 tibody A AA, AO A AntiB B BB, BO B AntiA AB AB A and B None O OO H AntiA AntiB ? (二 ) Hemolytic disease of the newborn 新生兒溶血癥 (erythroblastosis fetalis) 胎兒紅細胞增多癥 type: ? : penicillin → degrade → BPO(hapten)+RBC → AntiBPO ? → penicillin again → RBCBPOAntiBPO → Complement→ hemolytic anemia (三 ) Immune Hemolytic Anemia 免疫溶血性貧血 type: Medicine (Hapten) + tissue pro → Ab → medicine again → Hapten + Ab → IC → C3b, Fc → RBC, Platelet, neutrophil (hemolytic anemia 溶貧 , thrombocytopenia 血小板減少性紫癜 , neutropenia 中性白細胞減少癥 ) ? (hemolytic) anemia ? αMethyldopa甲基多巴 → RBC ? ’s syndrome肺腎綜合征 ? (20%)腎小球腎炎 Commom Ag(streptococcus and glomerular basement membrane) ? (四 ) Autoimmune Diseases: ① Grave’s Disease 甲狀腺功能亢進 LATS長效甲狀腺刺激素 → Thyroid 甲狀腺 → Thyroxine甲狀腺素 ② Myasthenia gravis重癥肌無力 : AntiAchR ③ Diabetes Mellitus of Insulin Resistance胰島素抗性糖尿病 : AntiInsulin R 5. Autoimmune receptor disease: Type Ⅲ Hypersensitivity 一、 Pathogenesis: (一 ) IC formation and deletion: (IC mediated, vasculitis type血管炎型 ) of IC: ① soluble Ag ② IgG(mainly) ③ Ag Ab Ratio: Ag : Ab IC AgAb 19s Ag = Ab 19s AgAb Arthus Ag Ab ≈19s of IC IC→ plement → C3a、 C5a 、 C3b → neutroplil → vasculitis血管炎 basement membrane of the kidney 腎小球基底膜 membrane of joints 關(guān)節(jié)滑膜 plexus of the brain 腦脈絡(luò)叢 (二 ) local deposition of IC (三 ) Pathogenesis of IC: (一 ) local IC diseases: 1. Arthus reaction 2. Allergic pneumonitis變應(yīng)性肺泡炎 3. IgA nephropathy腎病 二、 Common Diseases in Clinical: (二 ) Systemic IC diseases: sickness: Xenogenic serum injection→ 7~ 14d→ sickness streptococcal glomerulonephritis 鏈球菌感染后腎小球腎炎 Streptococcal infection → 2~3w → IC → deposites in glomerular basement membrane and subepithelium上皮細胞 80% glomerulonephritis(by IC) (三 ) Chronic IC diseases: 1. SLE系統(tǒng)性紅斑狼瘡：抗核抗體 2. RA類風濕性關(guān)節(jié)炎：抗變性 IgG抗體
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