傅繼梁同濟大學醫(yī)學與生命科學部(編輯修改稿)
2025-08-14 09:14 本頁面
【文章內容簡介】 s)。 基因調控元件 (如啟動子 )所含 CpG島中的 5mC會阻礙轉錄因子復合體與 DNA的結合，所以DNA甲基化一般與基因沉默 (gene silence)相關聯(lián)；而非甲基化 (non methylated)一般與基因的活化 (gene activation)相關聯(lián)。而去甲基化(demethylation)往往與一個沉默基因的重新激活 (reactivation)相關聯(lián)。 DNA甲基化 Model for methylationdependent gene silencing. The structural element of chromatin is the nucleosomal core, which consists of a 146bp DNA sequence wrapped around core histones. Acetylation of the histones causes an open chromatin configuration that is associated with transcriptional activity. Methylated cytosines are recognized by methylCpGbinding proteins (MBDs), which
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