【正文】 由于夾套的介質(zhì)為水或水蒸氣，介質(zhì)對(duì)材料的腐蝕性輕微，故選用Q235A 為夾套材料，查手冊(cè)知道板厚為 ~16 mm。作為水溶液比熱容的近似計(jì)算，可先求出固體的比熱容，再按下式計(jì)算C=CS a + (1a)式中 C水溶液的比熱容 KJ/(Kg.℃)。所以確定損耗=總投料量%=（++ ）%=?；瘜W(xué)反應(yīng)方程式為： OHOOH H3COH3COCOH3 OHOOCH3H 生產(chǎn)工藝流程確定 生產(chǎn)工藝流程—酰化—酸洗離心—水洗離心—?dú)饬鞲稍铩L(fēng)分離—阿司匹林 工藝流程圖水楊酸酸酐母液?；?酸洗離心 水洗離心 氣流干燥母液旋風(fēng)分離阿司匹林 工藝過程說明 醋化崗位第一次投料：按醋酐總量與含量計(jì)算水楊酸總投料量，檢斤稱重，將總投料量的三分之二水楊酸投入醋化罐中，再將醋酐一次全部加入罐中，在攪拌情況下，水汽加熱 1h，使內(nèi)溫升到 80℃～84℃，析出晶體，保溫 40min～60min后，緩慢均勻降溫到 55℃。其中，河北敬業(yè)化工集團(tuán)醫(yī)藥化工分公司生產(chǎn)規(guī)模達(dá)到 3000 噸，年產(chǎn)量為 2500 噸；陜西華陰錦前程藥業(yè)有限公司生產(chǎn)規(guī)模達(dá)到 2500 噸，年產(chǎn)量達(dá) 2022 噸，成為阿司匹林生產(chǎn)的后起之秀。艾興格林的指導(dǎo)下，并且完全采用艾興格林提出的技術(shù)路線才獲得成功的。1934 年，費(fèi)利克斯 粉末外用治足癬。生產(chǎn)中還可產(chǎn)生醋酸苯酯、水楊酸苯酯和乙酰水楊苯酯。目 錄目錄 .................................................................................................11 概述 ............................................................................................3 阿司匹林的的性質(zhì) .............................................................................4 理化性質(zhì) .......................................................................................4 臨床上用途 ...................................................................................4 發(fā)展簡(jiǎn)史 .............................................................................................5 國內(nèi)外生產(chǎn)現(xiàn)狀 .................................................................................6 市場(chǎng)分析 .......................................................................................6 生產(chǎn)情況 .......................................................................................6 市場(chǎng)情況 .......................................................................................72 生產(chǎn)工藝 ....................................................................................7 設(shè)計(jì)內(nèi)容 .............................................................................................7 生產(chǎn)工藝 .............................................................................................7 生產(chǎn)工藝流程確定 .............................................................................8 生產(chǎn)工藝流程 .............................................................................8 工藝流程圖 .................................................................................8 工藝過程說明 ....................................................................................8 醋化崗位 .....................................................................................8 酸洗離心洗滌 .............................................................................9 水洗離心洗滌 .............................................................................9 干燥崗位 .....................................................................................9 回收崗位 .....................................................................................93 物料衡算 ....................................................................................9 溶解罐的物料衡算 .............................................................................9 ?；磻?yīng)的物料衡算 .......................................................................11 滲濾槽的物料衡算 ...........................................................................12 酸洗離心機(jī)的物料衡算 ...................................................................13 水洗離心機(jī)的物料衡算 ...................................................................14 流化床的物料衡算 ...........................................................................164 能量衡算 ..................................................................................16 反應(yīng)罐能量衡算 ..............................................................................16 比熱容的計(jì)算 ...........................................................................17 能量衡算 .....................................................................................185 主要工藝設(shè)備計(jì)算 ....................................................................19 工藝設(shè)備選型原則 ...........................................................................19 工藝設(shè)備計(jì)算 ...................................................................................19 醋化反應(yīng)釜 .................................................................................19 夾套的計(jì)算 ...............................................................................20 筒體的材料和壁厚 ...................................................................22 水壓試驗(yàn)及其強(qiáng)度校核 ...........................................................23 選擇釜體法蘭 ...........................................................................24 選用手孔、視鏡、溫度計(jì)、和工藝接管 ...............................25 攪拌器的設(shè)計(jì)計(jì)算 ...................................................................26 容器支座的選用計(jì)算 ...............................................................26 酸洗離心機(jī) .......................................................................................26 水洗離心機(jī) .......................................................................................26 振動(dòng)流化床干燥器 ...........................................................................27 母液蒸餾罐 .......................................................................................27 循環(huán)母液反應(yīng)罐 ...............................................................................276 管道設(shè)計(jì) ..................................................................................27 管道計(jì)算 ...........................................................................................27 水楊酸的進(jìn)料管道的計(jì)算 .........................................................28 酸酐的進(jìn)料管道的計(jì)算 .............................................................28 母液的管道進(jìn)料計(jì)算 .................................................................287 車間布置設(shè)計(jì) ...........................................................................29 概述 ...................................................................................................29 車間布置設(shè)計(jì)的依據(jù) ..............................................