羥基的保護(hù)與去保護(hù)藥明康德講座(更新版)
【正文】 Effect of solvent on the hydrogenlysis of benzyl ether 14 芐基醚保護(hù)與去保護(hù)事例 OO T rA c H NH OO M eOO T rA c H NB n OO M eB n B r , N a H12D M FB u l l . C h e m . S o c . J p n . 1 9 8 7 , 6 0 , 1 5 2 91 2OO HOOK2C O3/ E t O HB n C lOA c H N O B nM e ON H A cHH3COA c H N O HM e ON H A cHH3C1 0 % P d / C / H234J . A m . C h e m . S o c . 1 9 7 1 , 9 3 , 1 7 4 615 對甲氧基芐基醚 甲氧基芐醚的合成與芐基醚相似。通常，幾乎任何酸性試劑或任何可以在原位產(chǎn)生酸的試劑都可被用來引入 THP基團(tuán)。 在大量其它保護(hù)基存在下有許多溫和的脫保護(hù)方法。 23 應(yīng)用事例 B n OO B nO B nO B nO HH OA l l y l B r / N a O HB n OO B nO B nO B nO HA l l y l O1 2J . O r g . C h e m . C 1 9 6 9 , 2 3 6 7R O C H2C H = C H2R h ( I )R O C H = C H C H3p H 23 4 5C H3C H2C H OR O H +J . C h e m . S o c . P e r k i n s T r a n s 1 , 1 9 8 0 , 7 3 8O HH OA c2O / D M A PO A cA c OO HA c OO A cH O++1 2 34J . O r g . C h e m . 1 9 9 3 , 3 7 9 1O HH OA c2O / T M S O T fO A cA c OO HA c OO A cH O+ +56 7 8J . O r g . C h e m . 1 9 9 8 , 2 3 4 224 應(yīng)用事例 NNC H3HO HC NNNC H3B zO B zC NB z C l / P y r1 2J . O r g . C h e m . 1 9 8 1 , 4 6 , 5 2 5 2O HC H3H OO HP v C l , P y rO P vC H3H OO H3 4J . A m . C h e m . S o c . 1 9 8 0 , 1 0 2 , 7 9 6 2NO A cC O2C H3HHNO HC O2C H3HHK2C O3/ M e O H1 2D e A c p r o t e c t i o nJ . A m . C h e m . S o c . 1 9 7 2 , 9 4 , 8 6 1 325 應(yīng)用事例 (去保護(hù) ) NNC H3B zO B zC NNNC H3B zO HC N1 2N a O H / M e O HAP v ON3O M sAH OH2NO M s341 . P d / B a C O3,2 . N a O M e / M e O HJ . O r g . C h e m . 1 9 8 1 , 4 6 , 5 2 5 2J . A m . C h e m . S o c . 1 9 9 0 , 1 1 2 , 3 6 9 326 Thanks and Comments!
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