現(xiàn)代脂質(zhì)三聯(lián)治療ppt課件(更新版)
【正文】 MMV Medizin Verlag, 1993: 43 5 High CHD risk Medium CHD risk Low CHD risk 35 3 PROCAM Heart Study Mean values for developing atherosclerotic CHD within 6 years Variable CHD Development No CHD Development (n = 186) (n = 4221) TC (mg/dl) HDLC (mg/dl) LDLC (mg/dl) LDL/HDL ratio TG (mg/dl) ASSMANN G。 MMV Medizin Verlag, 1993: 60 PROCAM Heart Study Expert Opinions Part IV The Lipid Triad Expert Comments AHA, November 1999 “Evaluating the risk on the bases of LDL alone, is naive” Valentin Fuster, Mount Sinai Medical Center, New York “The LDL/HDL ratio is a much stronger predictor for the CHD risk than LDL alone” Paul Ridker, Brigham Institute for Women’s Hospital, Boston ACCP, March 2022 “Low HDL is a better indicator of CHD than high LDL as seen in epidemiological studies such as the Framingham Study and recently the VAHIT Study.” Sander Robins, University Medical Center, Boston “Landmark statin trials have shown consistent benefits on CHD reduction after raising HDL by 5 10% irrespective of LDL levels” Christie Ballantyne, Baylor College of Medicine, Houston The Lipid Triad Expert Comments Helsinki Heart Study “The LDL/HDL ratio was the best single predictor of cardiac events” Manninen V, Leena T, Koskinen P et al. Circulation 1992。 144 (S 1): A 37 20,0 10,0 0,0 30,0 40,0 5 Placebo 35,0 25,0 15,0 5,0 Apo B/ Apo A1 Cerivastatin Pooled Data Data on file n = 588 n = 259 n = 265 n = 573 n = 658 n = 599 2,0 Patient Group Cerivastatin Placebo 100mg 200mg 300mg 400mg 800mg All Male Female ? 40 Years 40 65 Years ? 65 Years Elderly patients male female Cerivastatin Studies 8 Weeks Minimum Treatment Data on file Sales supporting activities Gaining consensus from OL Leading instead of Following Database LDL/HDL ratio Opinion Leaders Private Cardiologists GPs Spreading the Story Effectively Press Inter Publications
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