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y ? Survival ? Weather ? Housing ? Geography ? Occupational setting ? Air quality ? Food Factors Influencing Disease Transmission Distribution due to Socioeconomic ? Hepatitis A ? Typhoid fever ? Helicobacter pylori ? Other bacterial diarrheas ? Tuberculosis Characteristics of Infectious Diseases ? Pathogen ? Infectivity: isolation of patients ? Epidemiologic feature: continue with next slide ? Postinfection immunity Basic features Level of Epidemic ? Sporadic level occasional cases occurring at irregular intervals ? Endemic level persistent occurrence with a low to moderate level ? Hyperendemic level persistently high level of occurrence ? Epidemic or outbreak occurrence clearly in excess of the expected level for a given time period ? Pandemic epidemic spread over several countries or continents, affecting a large number of people Clinical Phage ? Incubation period (潛伏期 ) ? Prodromal period (前驅(qū)期 ) ? Manifestation period (癥狀期 ) ? Recovery phase (恢復期 ) ? Relapse (復發(fā) ): fully recover and disease reappeares ? Recrudescence (再燃 ): not fully recovered and got worser ? Sequela (后遺癥 ): functionally not fully recovered 1. Effervescence (increasing) 2. Fastigium (peaking) 3. Defervescence (decreasing) Symptoms and signs Fever Process Symptoms and signs Fever types Sustained Fever Remittent Fever Intermittent Fever (septic fever) Relapsing Fever (Undulant Fever) Saddle Type Fever Irregular Fever Fever type Sustained Fever Remittent Fever Intermittent Fever (septic fever) Undulant Fever Relapsing Fever Irregular Fever Skin Eruption Macule (班疹 ) Maculopapule (班丘疹 ) Roseola (玫瑰疹 ) Skin Eruption Petechiae (出血疹 ) Ecchymosis Herpes The Time Rash Appears Day 1 Rubella (風疹 ) Day 2 Scarlet Fever (猩紅熱 ) Day 3 Small Pox (天花 ) Day 5 Typhus Fever (班疹傷寒 ) Day 6 Typhoid (傷寒 ) Other Symptoms Conjunctiva congested Enlargement of lymph nodes ? Toxemic symptoms Bleeding Coma ? Mononuclearphagocyte system response Splenohepatomegaly Diagnosis ? Epidemiology vital and significant in diagnosis ? Clinical Manifestation such as rose rash, splenohepatomegaly, gastroemius tenderness ? Laboratory Test main means for diagnosis Laboratory Test ? Light Microscopy H amp。300:1639. 973重大項目 NSFC杰出青年和青年基金 國際核心期刊論文 優(yōu)秀博士生論文 韓梅芳 嚴偉明 習 東 Thanks for Your Attention! 。 Prof. Qin Ning (寧琴 ), MD. PHD Department of Infectious Disease, Tongji Hospita