脂質(zhì)體運(yùn)用于胰島素口服給藥治療糖尿病的可能性外文翻譯(存儲(chǔ)版)
【正文】 this nonspecific binding in the liposomes, the liposomes will not alter the structure of insulin, and thus will not affect the efficacy of insulin. Insulin is encapsulated within the bilayer wrapped liposomes, phospholipids and can promote the absorption of insulin from proteolytic enzymes to preserve insulin destruction and degradation of the immune system, to some extent, improved bioavailability, to ensure the efficacy, and can make the drug through the role of phospholipid bilayer slow controlled release, can play a steady drop in blood sugar. In recent years, insulin liposomes due to its broad prospects attracted more and more attention. In insulindependent diabetes mellitus, treatment with subcutaneous injections of insulin in adequate doses not only does not prevent the development of diabetic plications in many cases, in particular, liver pathology, but also promotes the appearance of lipodystrophies. Insulin injected in this way enters the general circulation earlier than the liver. On the contrary, under physiological conditions it immediately enters the liver through the portal vein from the pancreas, and 5060% of the newly secreted insulin is retained there . In view of this, the need for seeking a new means of introduction of the hormone lacking in the organism, closer to the physiological pathway, is understandable ..It would be most convenient to introduce insulin per os, if it were protected from the action of the proteolytic enzymes of the gastrointestinal tract. Repeated attempts have been made to introduce insulin into the organism without , for example, it has been suggested that a mixture of insulin with a vasodilating preparation be adsorbed under the tongue。脂質(zhì)體可制成各種大小的粒徑 , 通過(guò)改變磷脂的組成還可使脂質(zhì)體具有不同的表面性質(zhì) , 因此可適用于各種給藥途徑。 胰島素以這種方式注射進(jìn)入大氣環(huán)流 ，然后進(jìn)入 肝臟 ?？诜o藥后已檢測(cè) 出 胰島素的合成聚合物 可引起 血糖水平的降低。在實(shí)驗(yàn)中，我們使用128個(gè)非近交系的小 白鼠 。 胰島素在脂質(zhì)體中口服給藥后的僅 1小時(shí)就能 注意到在血液中的葡萄糖含量減少 ， .通過(guò)給藥后第 4 個(gè)小時(shí)的 反應(yīng) 愈演愈烈 。 一方面，由于缺乏 患有 胰島素血癥 的大鼠對(duì)照組中的量的增加 ，并在另一方面，通過(guò)檢測(cè) 出 低水平的血清 C肽，它是由 前 胰島素以等摩爾量與胰島素形成的 ，這兩方面證明了上述的那一點(diǎn)。 因此，在患有嚴(yán)重四氧嘧啶糖尿病 的動(dòng)物中 引進(jìn)胰島素到脂質(zhì)體提供了一個(gè)顯 著 的治療和長(zhǎng)期的影響（減少了精神萎靡，口渴，降低血糖水平，胰島 素血癥的水平顯著上升，并增加壽命） 。簡(jiǎn)單胰島素 以 相同劑量 進(jìn)行 皮下注射，每天一次 與 對(duì)照 組 動(dòng)物 比較 ， 24 小時(shí)后 健康狀況 沒(méi)有 得到 改善，血糖水平在這個(gè)期間 仍然 是高的，盡管胰島素血癥增加 。大多數(shù)動(dòng)物的 健康狀況 是顯著 提高 ，它們變得更加活躍。在血清中的 C 肽 含量 明顯 比 健康動(dòng)物低 。 該方法 在有些文獻(xiàn)上被 詳細(xì)描述 過(guò)。 也有人建議胰島素 作為 水 油乳劑給予動(dòng)物十二指腸的降血糖效果 。近年來(lái) , 胰島素脂質(zhì)體由于其廣闊的研究前景受到了越來(lái)越多的關(guān)注。研究使用方便 , 療效確切 , 安全可靠的胰島素新制劑是國(guó)內(nèi)外醫(yī)藥界共同關(guān)注的課題。 however, the necessity of using large doses of the preparation over a prolonged period of time prevents the introduction of this method into clinical sugarlowering effect of insulin administered to animals intraduodenally in a wateroil emulsion has also been suggested .Effectiveness of rectal introduction of insulin in the form of an emulsion or suppositories has been reported in a number of studies~ A decrease in the blood sugar level has been detected after oral administration of insulin with
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