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GOD])/ DGGO 100, where DGGO is the largest diameter of the entire lesion and D is the largest diameter of the solid component within the lesion.,第十二頁,共四十頁。,type II (passthrough), vessels passed through the lesions without obvious morphological changes in traveling path or size .,第十六頁,共四十頁。,Statistical analysis,SPSS 16.0 for Windows, SPSS, Chicago, Ill Independent t test was used to compare different pathological groups (benign diseases, preinvasive diseases and invasive adenocarcinoma) of GGN. Correlations between pathological findings of GGNs and GGNvessel relationships were examined using Spearman’s rank test. GGNvessel relationships between MIA and IAC diseases were compared using Pearson’s chisquared test. When there was an expected value 1 or a pretest probability close to the test level, Fisher’s exact test was used instead. Statistical results were considered significant when the P value was less than 0.05.,第二十頁,共四十頁。6.0 mm, respectively. No significant differences existed between the preinvasive group and the benign group (t = ?0.64,p=0.53). However, there were significant differences between benign and preinvasive groups and the invasive adenocarcinoma group (t = ?6.31,p=0.00。,MIA could present four types, with type II as the major type (48.7 %). The combination of type II and IV comprised about 80 % of the MIA subgroup。,Discussion,Solitary pulmonary nodules (SPNs) are common findings in CT examinations and can be divided into two groups based on density variation: solid nodules and GGNs. In 2011, the International Association for the Study of Lung Cancer, the American Thoracic Society and the European Respiratory Society proposed a new classification for lung adenocarcinomas. In the new classification system, the term bronchioloalveolar carcinoma (BAC) is no longer used. The former BAC concept applicable to multiple categories in the new classification system, such as AIS, MIA and the mucinous subtype of adenocarcinoma. Both AIS and AAH lesions are classified as preinvasive adenocarcinoma under the new classification system,第二十七頁,共四十頁。,This demands further investigation of this particular abnormal imaging finding to minimise misdiagnosis. In the management of GGNs in our patients, clinical guidelines from the Fleischner Society and National Comprehensive Cancer Network (NCCN) were referenced . Each individual case was discussed by a multidisciplinary team, including diagnostic radiologists, thoracic surgeons and pathologists, to generate consequent management strategies. All patients received adequate followup observation with/without supportive or antiinflammatory treatment, which explained the fact that four GGNs disappeared prior to the next scheduled CT examination.,第三十頁,共四十頁。,As a result , involved vessels might appear distorted, rigid or concentrated towards the lesion. Thus, it is reasonable to postulate假設(shè)(jiǎsh232。,Some studies have shown that endogenous and/or extrinsic tumor angiogenesis and neovascularisation could be the driving factors of vascular abnormalities observed in malignant early stage. As a CT imaging sign, VCS describes a relationship between SPNs and vessels, one or multiple vessels concentrating towards and passing through lesions or being truncated at the edge of lesions.,第三十六頁,共四十頁。,內(nèi)容(n232。,