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12 Company Logo 13 Company Logo progressive angina Plaque rupture Unstable angina Acute MI stable angina Pathophysiology of CAD 14 Company Logo What Are the Results of Atherosclerosis? Results: ? silence ? ischemiaangina pectoris, TIA, claudication ... ? necrosisMI, stroke... ? fibrosisischemia cardiomyopathy/nephropathy/dementia... Ⅱ Risks Factors 16 Company Logo Ⅱ Risks of Atherosclerosis ? Age ? Family history ? Gender ? Cigarette smoking ? Lowdensity lipoprotein cholesterol (dyslipidemia) ? Hypertension ? Diabetes mellitus ? Estrogen deficiency ? Inactivity ? Obesity ? others: Atype character, high TG, high homocysterine... 17 Company Logo ?Unmodifiable risks ?Modifiable risks 18 Company Logo Unmodifiable risks ?Age ?Family history ?Gender 19 Age unmodifiable risks(1) ?Chances of a person having atherosclerosis are directly proportional to age. ?peak incidence of clinical manifestation, male ,5060y。s angina ?Injurytrauma Ⅰ Atherosclerosis A kind of clinical vascular disease 9 Company Logo atherosclerosis Cerebrovascular disease Coronary artery disease Peripheral artery disease 10 Company Logo Atherosclerosis ?Atherosclerosis is an ongoing process affecting mainly large and mediumsized arteries。 living in San Francisco, highest but still lower than American, only half of American39。326:242250, with permission. 50 Company Logo how to treat CHD? wait and see detail in lesson of AP and AMI 51 Company Logo ?attention: key points are in red colo